Clinical and Basic Neurobiology of Nervous System Diseases

描述（由申请人提供）：通过教育和让基础神经科学家参与以疾病为导向的研究，可以最好地减少神经系统疾病带来的巨大残疾和痛苦负担。为了实现这一目标，我们计划为耶鲁大学所有神经科学研究生开设一门“神经系统疾病的临床和基础神经生物学”课程，并将其提供给全国其他神经科学培训项目。该课程将成为NIH支持的“跨部门神经科学计划”（INP）的一部分（5T32 NS 41228， H. Keshishian PI）。新课程将比目前20个讲座的“神经疾病的细胞和分子机制”课程增加一倍以上，该课程侧重于神经退行性疾病。这两个课程共44个讲座，涵盖神经病学、精神病学和儿童精神病学领域的广泛疾病和障碍。除了讲座和书面教学大纲外，将为44堂课中的每堂课创建教程，利用基于网络的交互式格式的文本，图形，图形，动画和视频剪辑，让学生参与回答问题并与图形或动画互动，这些图形或动画会产生即时反馈，并提供表明掌握水平的总分。每个讲座-教学大纲-教程将包括疾病的描述、流行病学、遗传学、病例报告、临床课程、诊断方法、治疗、疾病的动物模型（重点是特定和常见的发病机制的神经生物学机制），以及对转化研究的社会和伦理方面的讨论。该课程将由一个执行咨询委员会指导，该委员会由两名共同主要研究员（一名临床科学家和INP的首席研究员）和来自神经病学、精神病学和儿童学系的其他三名成员领导

DESCRIPTION (provided by applicant): The immense burden of disability and suffering produced by nervous system diseases can best be reduced by educating and involving basic neuroscientists in disease oriented research. To accomplish this we plan to develop a course on the "Clinical and Basic Neurobiology of Diseases of the Nervous System" for all neuroscience graduate students at Yale University and make it available to other neuroscience training programs across the country. The course will be part of the NIH supported "Interdepartmental Neuroscience Program" (INP) (5T32 NS 41228, H. Keshishian PI). The new course will more than double the current 20 lecture course "Cellular and Molecular Mechanisms of Neurologic Disease", which focuses on neurodegenerative diseases. The 2 courses will include a total of 44 lectures covering a wide range of diseases and disorders from the fields of Neurology, Psychiatry and Child Psychiatry. In addition to lectures and a written syllabus, tutorials will be created for each of the 44 lectures utilizing text, graphics, figures, animations and video clips in a web based interactive format to engage students in answering questions and interacting with figures or animations that generate immediate feedback and provide a total score indicating the level of mastery. Each lecture-syllabus-tutorial will include a description of the disease, epidemiology, genetics, case presentations, clinical course, diagnostic methods, treatment, animal models of disease (with a focus on both specific and common neurobiologic mechanisms of pathogenesis), and a discussion of social and ethical aspects of translational research. The course will be directed by an executive-advisory committee led by the 2 co-principle investigators - (a clinician scientist and the principal investigator of the INP) with 3 other members from the Departments of Neurology, Psychiatry and Child Psychiatry and teaching faculty will come from these same 3 organizations. The course will be evaluated with a variety of subjective and objective measures including student scores on the tutorials. The course will have an impact outside Yale University since a webcast of the lecture, the syllabus, and the tutorials will be made available via the internet to other Neuroscience Training Programs. Relevance: The education of basic neuroscience graduate students in the neurobiology of diseases of the nervous system will foster their involvement in disease-oriented research and lead to improved prevention and treatment.