Metals and Campylobacter jejuni virulence: insights to control the most common bacterial cause of food-borne infection

该项目将实施多学科方法，以了解食源性病原体弯曲杆菌中的金属处理系统，以及这些系统对克服食物链中以及宿主定植和感染期间遇到的金属中毒的贡献。弯曲杆菌是人类急性胃肠炎的主要细菌原因，也是农业食品工业中新抗菌剂和控制策略的目标。因此，该项目与UKRI-BBSRC的主题“推进生物科学发现的前沿-了解生活规则”相关，并应对“可持续农业和食品生物科学”的战略挑战，重点关注全球主要挑战“粮食安全”和关键目标“通过利用微生物学的基础知识来提高食品安全，以最大限度地减少食品系统中的病原体”。学生将获得微生物学，感染生物学，生物化学和化学接口技术的培训和经验，为学术界和工业界未来的专业工作申请提供竞争优势。

The project will implement a multidisciplinary approach to understanding the metal handling systems in the food-borne pathogen Campylobacter and the contribution of these systems to overcoming metal intoxication encountered within the food chain and during host colonisation and infection. Campylobacter is the leading bacterial cause of human acute gastroenteritis and a target for new antimicrobials and control strategies in the agri-food industry. The project therefore has relevance to the UKRI-BBSRC theme 'advancing the frontiers of bioscience discovery-understanding the rules of life', and tackling the strategic challenge 'bioscience for sustainable agriculture and food', focussing on the major global challenge 'food security' and key objective 'to improve food safety through exploiting fundamental knowledge in microbiology to minimise pathogens in the food system'. The student will gain training and experience in techniques interfacing microbiology, infection biology, biochemistry and chemistry, providing a competitive advantage for future professional job applications both to academia and industry.