Mathematical Modeling of Human and Rodent Energy Metabol

我们的实验室继续在人类和啮齿类动物中开发全身能量代谢，宏量营养素利用以及体重和成分调节的现实数学模型。我们的计算框架集成了各种生理数据来构建单个模型组件，然后将其集成以计算整个系统的行为。该模型使用饮食中的碳水化合物、脂肪和蛋白质作为模型输入，计算全身能量消耗、底物氧化速率、新生脂肪生成、糖异生以及由此产生的体重和组成变化。

Our laboratory continues to develop realistic mathematical models of whole-body energy metabolism, macronutrient utilization, and the regulation of body weight and composition in both humans and rodents. Our computational framework integrates a variety of physiological data to construct the individual model components which are then integrated to compute the behavior of the entire system. The models use dietary carbohydrate, fat, and protein as model inputs to compute whole-body energy expenditure, substrate oxidation rates, de novo lipogenesis, gluconeogenesis, and the resulting changes in body weight and composition. The computational models are being used to study regulation of body weight and energy metabolism in the normal human and rodent, as well as alterations of metabolism that occur in conditions such as obesity, diabetes, and wasting syndromes like cachexia and anorexia. Continued development of our models is facilitating the investigation of various therapeutic interventions and their effects on metabolism, body weight and composition.