The roles of the COXs in normal physiology and pathology

这些研究的主要目的是利用COX缺陷小鼠阐明COX-1和COX-2在正常生理和不同病理状态下的个体作用。这些研究包括COX亚型在胃溃疡、肺部炎症和血管发育中的作用。我们对COX基因缺陷小鼠的早期研究是研究胃溃疡、炎症反应和肾脏发育。实验室最近的兴趣是研究COX缺乏对肺部炎症和粘液产生的影响。此外，实验室内的工作主要集中在使用COX-1和COX-2缺陷的ES细胞来研究COX在内皮细胞发育中的作用。研究表明，COX-1或COX-2的缺失并不抑制ES细胞向内皮细胞的分化。对COX-1和COX-2选择性抑制剂的研究表明，COX-2抑制剂通过COX依赖的机制抑制上皮细胞的发育。

The major goals of these studies are to elucidate the individual roles of COX-1 and COX-2 in normal physiology and in various pathological states using the COX deficient mice. Included in these studies are the roles of the COX isoforms in gastric ulceration, lung inflammation and vascular development. Our early studies in COX deficient mice was to investigate gastric ulceration, inflammatory responses and kidney development. More recent interest in the laboratory has been to study the effects of COX deficiency on lung inflammation and mucus production. Additionally, effort within the laboratory has focused on using COX-1 and COX-2 deficient ES cells to study the roles of the COXs in endothelial cell development. Studies suggest that the deficiency of COX-1 or COX-2 do not inhibit ES cell differentiation into endothelial cells. Studies with COX-1 and COX-2 selective inhibitors have been used and the data obtained suggest that the COX-2 inhibitor inhibits epithelial cell development by a COX dependent mechanism.