Efficacy of Laryngeal High-Speed Videoendoscopy

描述(申请人提供)：发声过程中正常声带振动中断所致的嗓音障碍。目前评估嗓音障碍的金标准是通过视频频闪检查进行视觉内窥镜检查。然而，频闪成像固有的技术限制(即，生成跨多个振动周期组装的复合图像)限制了视频频闪成像的临床和研究用途。高速成像有可能捕捉到声带真实的周期间振动行为，这在理论上应该克服了视频频闪检查的局限性，并为更准确地客观量化声带振动行为提供了可能性。声带高速成像有很长的研究历史，而相对较近的商业引入喉部高速视频内窥镜(HSV)有助于增加其临床和研究用途。然而，这些HSV系统尚未得到广泛采用，原因是仍然存在方法学上的局限性(例如，图像质量受损；缺乏提取丰富视觉内容的工具；难以管理和分析HSV产生的海量数据等)，以及相关的缺乏关于HSV的有效性、实用性和临床相关性的信息。本项目的主要目的是开发改进的基于HSV的声带振动特征可视化和自动测量方法，以促进该技术的临床和研究应用，并开始建立HSV在声带病理功能评估中的临床有效性、实用性和相关性。最重要的假设是，HSV可以发展成为一种强大的工具，将提供对喉音产生的生物力学的新见解(特别是当与其他同时测量相结合时)，并能够对嗓音疾病的病理生理学进行更准确的功能评估，从而在声带病理诊断中进行重要的改进。主要目的是进行一系列实验，以改进HSV技术，开发分析技术，建立临床方案，收集数据，并评估HSV在嗓音障碍临床评估中的可靠性、有效性和相关性。该项目提出了一种综合的方法，通过领先的科学家和临床医生的合作来解决所有上述任务。

DESCRIPTION (provided by applicant): Voice disorders result from the disruption of normal vocal fold vibration during phonation. The current gold standard for assessing voice disorders is visual endoscopic examination via videostroboscopy. However, technical limitations that are inherent to stroboscopic imaging (i.e., generating a composite image that is assembled across many cycles of vibration) restrict the clinical and research utility of videostroboscopy. High-speed imaging has the potential to capture the true cycle-to-cycle vibratory behavior of the vocal folds, which should theoretically overcome the limitations of videostroboscopy, and provide the potential for more accurate objective quantification of vocal fold vibratory behavior. Vocal fold high-speed imaging has a long research history, and the relatively recent commercial introduction of laryngeal high-speed videoendoscopy (HSV) has served to increase its availability for clinical and research use. However, these HSV systems have not gained widespread adoption because of remaining methodological limitations (eg., compromised image quality; lack of tools to extract the rich visual content, difficulty managing and analyzing the massive amounts of data generated by HSV, etc.), and an associated lack of information regarding the validity, practicality, and clinical relevance of HSV. The primary purpose of this project is to develop improved HSV-based methods for the visualization and automatic measurement of vocal fold vibratory characteristics that will facilitate the clinical and research use of this technology, and to begin establishing the clinical validity, practicality, and relevance of HSV in the functional evaluation of vocal fold pathology. The overriding hypothesis is that HSV can be developed into a robust tool that will provide new insights into the biomechanics of laryngeal sound production (particularly when combined with other simultaneous measures), as well as enable more accurate functional assessment of the pathophysiology of voice disorders leading to important refinements in the diagnosis of vocal fold pathology. The primary purpose requires a series of experiments to improve HSV technology, develop analysis techniques, establish a clinical protocol, collect data, and evaluate the reliability, validity, and relevance of HSV in the clinical assessment of voice disorders. This project proposes a comprehensive approach addressing all of the above tasks, through the collaboration of leading scientists and clinicians.