New Nanoparticles for Antimicrobial Therapy of Dental Plaque Related Diseases

描述（由申请人提供）：细菌生物膜在牙齿表面（牙菌斑）上的积累是导致一些最普遍的细菌引起的人类疾病的原因。这些疾病包括龋齿和牙周病。目前用于大多数牙菌斑相关疾病的治疗方案需要通过钻除受感染的牙釉质和牙本质以用于龋齿损伤，或通过慢性牙周炎中的根表面清创来机械去除牙菌斑/致病微生物，这是一种劳动密集且令人不愉快的程序，其将牙菌斑从牙周袋内部刮除。由于这些疾病与特定的微生物或微生物群有关，因此人们越来越关注使用抗菌剂来补充这些机械程序。该提案涉及开发一种新的抗微生物光敏剂，用于牙科工业中治疗各种口腔疾病，包括龋齿病变和牙周炎。抗菌光动力疗法（PDT）提供了一个有吸引力的替代其他局部抗菌剂。光敏剂可以直接应用于感染部位，在光的存在下，微生物可以在几秒钟或几分钟内被根除。细菌不太可能对这种类型的药剂产生耐药性，并且可以避免口腔中正常微生物群落的干扰，因为该药剂应用于斑块/感染部位。在第一阶段项目中，Lynntech将为牙科行业用于治疗牙菌斑相关疾病的新型抗菌光敏剂提供良好的技术基础。与公共卫生的相关性：一种有效杀死牙菌斑内细菌的方法可能会对牙科领域产生巨大影响，使牙医能够在修复病变之前避免在腔体中钻取受感染的牙本质，使手术对患者的创伤更小，对牙医来说更快。这种新的光敏剂还具有治疗牙周炎的能力，避免了与抗生素治疗相关的缺点，提供了更快的杀灭时间，并且没有细菌耐药性。

DESCRIPTION (provided by applicant): The accumulation of bacterial biofilms on tooth surfaces (dental plaque) is responsible for some of the most widespread bacterially induced diseases of man. These diseases include both caries and periodontal disease. Current treatment regimes for most plaque related diseases requires the mechanical removal of plaque/causative microorganisms, by drilling away of infected enamel and dentine for caries lesions, or by root surface debridement in chronic periodontitis, a labor intensive and unpleasant procedure which scrapes the plaque away from inside the periodontal pocket. Because these diseases are associated with specific microorganisms, or groups of microorganisms, there is an increasing interest in the use of antimicrobials to supplement these mechanical procedures. This proposal concerns the development of a new antimicrobial photosensitizing agent for use in the dental industry for the treatment of various oral diseases, including caries lesions and periodontitis. Antimicrobial photodynamic therapy (PDT) offers an attractive alternative to other topical antimicrobial agents. A photosensitizer can be applied directly to the infection site, and in the presence of light, microorganisms can be eradicated in seconds or minutes. Bacteria are unlikely to develop a resistance to this type of agent, and the disturbance of the normal microflora in the mouth can be avoided since the agent is applied at the site of the plaque/infection. During the Phase I project, Lynntech will provide a sound technical basis for a new antimicrobial photosensitizer for therapeutic use in the dental industry for dental plaque related diseases. Relevance to Public Health: A way to effectively kill bacteria within dental plaque could have an enormous impact on the field of dentistry, allowing dentists the means to avoid drilling of infected dentine in a cavity before restoring a lesion, making the procedure less traumatic for the patient and quicker for the dentist. The new photosensitizer also has the capability of treating periodontitis avoiding the drawbacks associated with antibiotic therapy, providing faster killing times and no bacterial resistance.