Development of multispectral imaging to measure oxygenation in skin

该项目旨在评估多光谱成像(MSI)是否可以用于测量系统性硬化症(SSC)患者皮肤的血氧含量。MSI提供了对大片区域(在这种情况下是整只手)成像的能力，并产生了氧合的图像地图。目标是测试、改进和开发一种光学系统来实现这一点，并配备相关的分析软件。学生将首先评估现有的MSI系统，开发用于分析的成像协议和软件。这将在患者和健康对照组中进行试验(与共同监督者工作的索尔福德NHS信托基金合作)。然后，他们将继续改进光学系统(硬件和软件)，以实现更高的精确度和重复性，目的是开发一种可用于监测SSC进展的系统。将对光在组织中的传输、散射和吸收进行建模，并对这些模型进行比较，看看哪种模型提供了最准确和可靠的计算氧合的方法。该项目包括光学硬件、组织光学(光子传输)、成像、软件和详细的数据分析。

The project aims to assess whether multispectral imaging (MSI) can be used to measure blood oxygenation in the skin of patients with systemic sclerosis (SSc). MSI offers the ability to image large areas (whole hands in this case) and produce an image map of oxygenation. The objectives are to test, improve and develop an optical system to do this, with associated analysis software. The student will start by assessing an existing MSI system, developing an imaging protocol and software for analysis. This will be trialed with patients and healthy controls (collaborating with the Salford NHS trust where the co-supervisor works). They will then move on to improving the optics (hardware and software) to achieve increased accuracy and reproducibility, with the aim of developing a system that can be used to help monitor the progression of SSc. The transmission, scattering, and absorption of light in tissue will be modelled and these models will be compared to see which provide the most accurate and reliable method of calculating oxygenation.The project contains aspects of optics hardware, tissue optics (photon transport), imaging, software and detailed data analysis.