GENETICALLY MODIFIED RHESUS MONKEYS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。长期目标是生产转基因恒河猴，作为人类神经遗传性疾病的模型。我们的工作假设是，基因靶向和体细胞克隆技术相结合，可以为产生准确代表人类疾病的可靠动物供应提供基础。我们将集中在三个，早发性，功能丧失的条件：卡尔曼氏综合征，莱施尼汉氏病和共济失调毛细血管扩张症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal is to produce genetically-modified rhesus monkeys that will serve as models for human neurogenetic diseases. Our working hypothesis is that gene targeting and somatic cell cloning technology can, in combination, provide the basis for generating a reliable supply of animals that accurately represent human disease. We will focus on three, early-onset, loss-of-function conditions: Kallmann's syndrome, Lesch-Nyhan's disease and Ataxia-Telangiectasia.