Investigation into fibrous architecture for disease management

迫切需要新的医疗保健方法来改善诸如高级别胶质瘤等难以治疗的疾病的管理。最近，我们设计了合适的纤维结构，用于手术时肿瘤的时间释放治疗。我们开发了新的生物3D打印胶质瘤模型，以评估这种药物定时释放对脑肿瘤细胞和微环境的影响；为了临床验证，我们与神经病理学家Azzam Ismail博士（St. James's Leeds）建立了合作关系。该项目旨在深入研究药物的释放时间，以便更好地了解和改善患者的治疗。

Novel healthcare approaches for the improved management of difficult to treat diseases such as high-grade gliomas are urgently required. Recently, we have engineered suitable fibrous architectures for the time-released treatment of tumours at time of surgery. We have developed novel 3D bioprinted glioma models to assess the effect of such timed-release of drugs on brain tumour cells and the microenvironment; for clinical validation we have established a collaborative link with the Neuropathologist Dr Azzam Ismail (St. James's Leeds). This project proposes to thoroughly investigate the time release of drugs for informed and improved patient treatment.