Diurnal Preference in Amish Families

描述（由申请人提供）：在这个职业发展奖申请，我将奠定基础的流行病学和遗传研究的昼夜节律在人群中。 这项研究的目的是获得有价值的信息，在不久的将来更全面的研究昼夜节律的规划。 先前的研究表明，昼夜偏好是可遗传的，昼夜节律钟的变化与衰老有关。 我们假设昼夜偏好，昼夜节律的组成部分，是可变的和可遗传的，在旧秩序阿米什人（OOA），它是与老化。 本研究的主要目标有三个方面：（1）在人群水平上研究人类昼夜偏好与衰老相关表型之间的关联;（2）描述昼夜偏好的遗传流行病学特征，包括全基因组连锁分析;以及3）评估腕动记录仪在昼夜节律研究中的有用性。 我们计划使用Horne-Ostberg问卷从1，000名Amish家庭心血管干预研究（AFCVIS）和300名Amish参与者中收集关于昼夜偏好的信息“创始人人群长寿基因研究”（LGFPS），这两项新启动的研究旨在研究心血管疾病，骨质疏松症和长寿的遗传决定因素。 此外，我们还将获得LGFP研究中200名志愿者的7天活动记录仪和睡眠日志记录。 在这些人中已经可以获得与衰老相关的表型和5 cM基因组扫描的广泛信息。 我们的目标是有效地扩大我们的数据收集，以研究昼夜偏好，并最终，昼夜节律。 这个建议的家庭研究在一个遗传同质的创始人人口与“老式”的生活方式提供了一个独特的机会，研究昼夜偏好在一个大的和自由生活的人群。

DESCRIPTION (provided by applicant): In this Career Development Award application, I will lay the foundation for epidemiological and genetic studies of circadian rhythm in human populations. This proposed study is designed to obtain valuable information for the planning of more comprehensive studies of circadian rhythm in the near future. Prior studies have suggested that the diurnal preference is heritable and changes in circadian clock are associated with aging. We hypothesize that diurnal preference, a component of circadian rhythm, is variable and heritable in the Old Order Amish (OOA) and it is associated with aging. The primary objectives of this research proposal are three-fold: (1) to investigate the association between human diurnal preference and aging-related phenotypes at a population level; (2) to characterize genetic epidemiology of diurnal preference, including a genome-wide linkage analysis; and 3) to evaluate the usefulness of actigraphy in the studies of circadian rhythm. We plan to collect information on diurnal preference using the Horne-Ostberg questionnaire from 1,000 participants in the Amish Family Cardiovascular Intervention Study (AFCVIS) and 300 Amish participants of the "Longevity Genes in Founder Populations Study" (LGFPS), two newly initiated studies designed for studying genetic determinants of cardiovascular diseases, osteoporosis, and longevity. In addition, we will obtain 7-day actigraph and sleep log records from 200 volunteers in the LGFP study. Extensive information on aging-related phenotypes and a 5-cM genome scan are already available in these people. Our goal is to efficiently expand our data collection to study diurnal preference, and eventually, circadian rhythm. This proposed family study in a genetically homogeneous founder population with an "old-fashioned" life style provides a unique opportunity to study diurnal preference in a large and free-living human population.