TRANSGENIC APPROACH TO METALLOPROTEINASE INDUCED CARDIOVAS REMODEL

描述（由申请人提供）：我们将建立一个中心，以促进 在南卡罗来纳州对心血管疾病的研究我们的COBRE专注于 心血管疾病是重要的，因为我们国家的公民 比全国其他地方更容易患心血管疾病为 因此，该州的两所医学院联合起来， 南卡罗来纳州COBRE心血管疾病。此次COME将显著 加强在南卡罗来纳州的联合努力，招募、培训和留住 具备多学科技能和充分的 基础设施：（1）在基本机制中有效协作 心血管疾病的研究，（2）在竞争中取得成功， 国家一级的NIH和其他择优审查的资金，以支持 并扩展他们的研究努力。提出的五项科学项目 来自五个不同地区的有才华的新招聘的终身教职员工 部门，三个高科技科学核心（转基因，成像， 微阵列/蛋白质组学）由杰出的研究人员指导， 在其专业领域的记录和一个行政/指导核心 包括拟议的中心。总体主题是心血管疾病 疾病源自最终的共同致病途径：增殖， 重塑、凋亡、转分化和血管生成，其中每一个都是 是一个或多个项目的重点。虽然主题重点是 在心血管方面，执行的工作主题是辅导。州 在国家一级的研究资金上竞争力较低， 对新的研究者进行有效的指导是研究的一个基本要素 发展规划该提案通过以下方式直接解决了这一需求：（1）配对 有针对性的调查人员与建立NIH资助的研究人员谁拥有 出色的辅导记录以及相关的关键专业知识; (2)开展有组织的技能获取和提高活动， 如研讨会、期刊俱乐部、务虚会和特别课程;（3） 保证获得必要的核心资源， （4）提供专业知识和技术支持，以优化其使用; 进度报告和评估的定期时间表（检查点） 国家一级的外部咨询委员会提供的重要援助 公认的科学家。

DESCRIPTION (provided by applicant): We will establish a center to promote the study of cardiovascular diseases in South Carolina. Our COBRE focus on cardiovascular disease is significant because the citizens of our state are more prone to cardiovascular disease than anywhere else in the nation. For this reason, the two medical schools in the state have united to develop the South Carolina COBRE on Cardiovascular Disease. This COME will significantly augment joint efforts in South Carolina to recruit, train and retain a critical mass of investigators with multidisciplinary skills and adequate infrastructure to: (1) collaborate effectively in fundamental mechanistic studies of cardiovascular diseases, and (2) compete successfully at the national level for NIH and other merit-reviewed funding required to support and extend their research endeavors. Five scientific projects proposed by talented, newly recruited tenure-track faculty from five different departments, three high tech scientific cores (transgenics, imaging, microarray/proteomics) directed by outstanding investigators with proven track records in their area of expertise and an administrative/mentoring core comprise the proposed center. The overarching theme is that cardiovascular diseases derive from final common pathogenic pathways: proliferation, remodeling, apoptosis, transdifferentiation and vasculogenesis, each of which is the focus of one or more projects. While the thematic focus is cardiovascular, the operant theme for implementation is mentoring. In states that are less competitive for research funding at the national level, effective mentoring of new investigators is an essential element of a research development plan. This proposal addresses this need directly by: (1) pairing targeted investigators with established NIH-funded researchers who have exceptional mentoring track records as well as relevant critical expertise; (2) developing structured activities for skills acquisition and enhancement, such as seminars, journal clubs, retreats and special courses; (3) guaranteeing access to essential core resources with sufficient scientific expertise and technical support to optimize their use; and (4) implementing a regular schedule (checkpoints) of progress reports and evaluation with critical assistance from an External Advisory Committee of nationally recognized scientists.