SCIENCE AND RESEARCH CORE

描述(由申请人提供)：该提案寻求通过缅因州七个机构之间的生物医学研究卓越网络(INBRE)继续支持缅因州的生物医学研究基础设施网络(BRIN)，并由荒漠山岛生物实验室(MDIBL)担任牵头机构。INBRE的总体目标是通过进一步发展我们的合作网络来增强和加强缅因州的生物医学研究能力，该网络由两个一流的研究机构(MDIBL，杰克逊实验室)，两个本科生和研究生学位授予机构(缅因州大学，大西洋学院)和三个本科学位授予机构(贝茨学院，鲍登学院，科尔比学院)组成，INBRE将在Brin建立的成功基础上，通过以比较功能基因组学为主题的多学科研究网络进一步加强生物医学研究基础设施，并为发展缅因州科学家的生物医学研究竞争力提供更多机会。研究网络中的共同假设是，脊椎动物模型的原始结构区域的保守，包括脊椎动物、硬骨鱼、鸟类和哺乳动物物种，预测了感兴趣蛋白质中功能区域的位置，并确定了潜在的新调控序列，可以使用这些比较模型在功能分析中进行测试。缅因州的INBRE将a)为参与机构的初级教员、博士后研究员和研究生提供研究支持和核心设施，b)为参与机构的本科生创造全年和季节性的研究和培训机会，c)向缅因州所有本科生和社区学院的学生和教职员工提供外展活动，并通过以上方式，D)作为本科生从事卫生研究事业和提高缅因州劳动力的科学技术知识的渠道。

DESCRIPTION (provided by applicant): This proposal seeks continued support for Maine's Biomedical Research Infrastructure Network (BRIN) through an IdeA Network of Biomedical Research Excellence (INBRE) among seven Maine institutions, with the Mount Desert Island Biological Laboratory (MDIBL) serving as lead institution. The overall goal of this INBRE is to augment and strengthen Maine's biomedical research capacity by further developing our collaborative network composed of two premier research institutions (MDIBL, The Jackson Laboratory), two undergraduate and graduate degree granting institutions (The University of Maine, College of the Atlantic), and three undergraduate degree granting institutions (Bates College, Bowdoin College, Colby College) INBRE will build on the successful foundation established by BRIN by further strengthening biomedical research infrastructure through a multidisciplinary research network with a thematic scientific focus in comparative functional genomics and with expanded opportunities for developing the biomedical research competitiveness of Maine scientists. The common hypothesis within the research network is that conservation of primary structure across orthologous genomic regions of vertebrate models, including elasmobranch, teleost, avian and mammalian species predicts the location of functional domains in proteins of interest, and also identifies potential novel regulatory sequences that can be tested in functional assays using these comparative models Maine's INBRE will a) provide research support and core facilities to junior faculty, postdoctoral fellows and graduate students at participating institutions, b) create year-round and seasonal research and training opportunities for undergraduate students at participating institutions, c) provide outreach activities to students and faculty at all undergraduate institutions and community colleges in Maine, and through the above, d) serve as a pipeline for undergraduate students to pursue health research careers and enhance the scientific and technical knowledge of Maine's work force.