750 Mhz NMR Console

描述（由申请人提供）：我们建议为750 MHz NMR光谱仪购买一个新的控制台，以支持华盛顿大学的三个主要用户（Varani、PI、Drobny和Klevit）和几个次要用户组的生物分子研究。参与者包括来自两个大学部门（生物化学和化学）的教师，他们有多个正在进行的NIH资助的项目，这些项目将从正在寻求的仪器中受益匪浅。华盛顿大学的核磁共振仪器包括四台500 MHz仪器和一台即将购买的配备冷冻探针的600 MHz光谱仪。升级750 MHz频谱仪将使西雅图的仪器接近目前在具有类似科学兴趣和临界质量的其他研究人员社区中常见的最先进水平。750 MHz光谱仪目前位于化学系，靠近设施经理（Rajan Paranji博士）的办公室和两个一流的电子和机械车间。光谱仪所在的房间最近已经由化学和生物化学系提供的资金进行了升级，以改善温度调节。PI最近购买了一个新探头。然而，该控制台的日期从1996年以来，并没有以任何重大的方式升级。升级控制台将通过提高溶液实验的性能并允许其用于生物分子的固态NMR实验（Drobny）来非常有利地影响主要用户的研究。对于当前的控制台，它们必须使用专用的自制控制台来执行。更新的电子设备所带来的光谱仪性能的提高将大大有利于所有用户。此外，新的控制台将减少与控制台故障相关的不可避免的停机时间，随着光谱仪的老化，控制台故障变得越来越普遍。

DESCRIPTION (provided by applicant): We propose to acquire a new console for the 750 MHz NMR spectrometer to support the biomolecular research of a group of three major users (Varani, PI, Drobny and Klevit) and several minor user groups at the University of Washington. The participants include faculty from two university departments (Biochemistry and Chemistry), who have multiple ongoing NIH-funded projects that will benefit significantly from the instrumentation being sought. NMR instrumentation at the University of Washington includes four 500 MHz instruments and a soon-to-be purchased 600 MHz spectrometer equipped with a cryoprobe. Upgrading the 750 MHz spectrometer will allow the instrumentation in Seattle to approach the state-of-the-art now common in other communities of researchers with similar scientific interests and critical mass. The 750 MHz spectrometer is currently located in the Chemistry Department near the office of a Facility Manager (Dr. Rajan Paranji) and two superb electronic and machine shops. The room where the spectrometer is sited has recently been upgraded with funds provided by the Department of Chemistry and of Biochemistry to improve temperature regularion. A new probe has been purchased recently by the PI. However, the console dates from 1996 and has not been upgraded in any significant way since then. Upgrading the console will very favorably impact the research of the major users by improving the performance for solution experiments and by allowing its utilization for solid state NMR experiments of biomolecules (Drobny). With the current console, they must be executed with a dedicated home-built console. The increase in spectrometer performance resulting from updated electronics will be greatly beneficial to all users. Furthermore, the new console will reduce the inevitable downtime associated with console failure, which are becoming increasingly common as the spectrometer ages.