Mitochondrial metabolism as a target for human metabolites of dietary anthocyanins

这项研究预计将产生证据，证明特定的花青素代谢物对线粒体代谢有有益的影响，并可能保护线粒体免于功能失调，例如当暴露于超理想的营养水平时（例如，在餐后阶段或在高危人群中，如诊断为糖尿病前期或代谢综合征的人群中）。这将引起健康专业人士的兴趣，包括营养师/临床医生，他们为有患代谢性疾病风险的人提供饮食建议。这些发现也会引起那些寻求开发和销售针对代谢功能障碍产品的营养保健公司的兴趣。在这个项目中，特定的花青素人类代谢物的鉴定会导致线粒体功能/能量代谢的有益变化，这可以为未来的研发奠定基础，以确定这些代谢物（可能是也可能不是花青素）的最佳来源，并随后开发新的营养保健品。这些数据还可以用于开发可以在长期内增加肠道中这些代谢物产生的前/前/合成生物制剂。如果这些体外观察得到适当设计和控制良好的人类饮食干预研究数据的支持，这项研究可以用来支持政策制定者改变饮食建议。

The research is expected to generate evidence that specific anthocyanin metabolites have beneficial effects on mitochondrial metabolism and may protect mitochondria from becoming dysfunctional, for example when exposed to supra-optimal nutrient levels (e.g., during the post-prandial phase or in at-risk groups such as those diagnosed as pre-diabetic or metabolic syndrome). This will be of interest to health professionals including dieticians/clinicians who provide dietary advice to people who are at-risk of developing metabolic disease. The findings will also be of interest to nutraceutical companies who are seeking to develop and market products that target metabolic dysfunction. The identification of specific anthocyanin human metabolites that cause beneficial changes in mitochondrial function / energy metabolism in this project can underpin future R&D to identify the best sources of these metabolites (which may or may not be anthocyanins) and subsequently the development of new nutraceutical products. The data could also be used to develop pre-/pro-/syn-biotics that can increase production of these metabolites in the gut in the longer term this research could be used to underpin changes in dietary advice from policy makers if these invitro observations were backed up by data from properly designed and well controlled human dietary intervention studies.