Beta Imager 2000Z Digital Imaging System

描述（由申请人提供）： 小动物成像已经成为药物开发和动物模型疾病理解的一个非常强大的工具。小动物成像技术的使用加快了基础科学研究向临床的转化。华盛顿大学医学院（WUSM）是新放射性药物和药物的概念和设计的世界领导者。两台最先进的微型PET断层扫描仪有助于筛选新的放射性药物。传统上，放射自显影已被用作确定示踪剂在小器官结构内的精确定位的金标准。这对于用具有短半衰期的正电子发射同位素（例如C-11）标记的新放射性药物变得更加困难。具有与放射自显影相当的分辨率但具有高灵敏度的仪器将非常有利于增强microPET成像，从而简化新放射性药物的设计和实施。Biospace a Imager提供了足够的分辨率来满足这些要求。该系统使用一种新的平行板雪崩探测器，采用闪烁技术和CCD相机，以更准确地定位每个衰变事件的网站。在a成像仪中，氩气和三乙胺蒸汽的气体混合物作为计数气体，而交叉线栅在3-4 kV下工作，是通常比例计数电压的两倍。在每个衰变事件中，电子雪崩产生气体闪烁;对于氩，每keV的β粒子能量产生约35个光子，输出中心为280 nm。光子形成一个点，然后由相机观察。不仅记录了该事件，还实时记录了监视器上的粒子来源。Biospace Beta成像仪提供200 mm x 250 mm的视场/样本尺寸，适用于整个小鼠成像和4级变焦。它具有异常的检测阈值（例如，3 H 0.007 cpm/mm 2; 14 C，35 S，33 p 0.01 cpm/mm 2; 32 p 0.1 cpm/mm 2）和空间分辨率（对于最小可检测特征，半峰全宽低至60 fm）以及像素分辨率至10 fm。效率（检测到的颗粒与从样品中出现的颗粒数量的比率）可以高达90%，在104的动态范围内线性度优于2%。该仪器由beta VISION +TM软件支持，用于图像分析，并可选择进行双同位素分析。来自WUSM的这一提议是为Biospace a Imager申请资金，以帮助药物和放射性药物的设计和应用，以改善来自广泛学科的研究人员，包括本体学，神经学，化学和肺部医学。

DESCRIPTION (provided by applicant): Small animal imaging has become a very powerful tool for both drug development and in the understanding of diseases in animal models. The use of small animal imaging technologies has expedited the translation of basic science research to the clinic. Washington University School of Medicine (WUSM) is a world leader in the concept and design of new radiopharmaceuticals and drugs. Aiding in the screening of new radiopharmaceutieals are two state-of-the-art microPET tomographs. Conventionally, autoradiography has been used as a gold standard for determining the exact localization of tracer within small organ structures. This has become more difficult for new radiopharmaceuticals labeled with positron-emitting isotopes with short half lives such as C-11. An instrument with comparable resolution to autoradiography, but high sensitivity, will be extremely beneficial to augment microPET imaging, therefore streamlining the design and implementation of new radiopharmaceuticals. The Biospace a Imager offers the adequate resolution to answer these requirements. The system uses a new Parallel Plate Avalanche Detector that employs scintillation techniques and a CCD camera to more accurately locate the site of each decay event. In the a Imager, a gaseous mixture of argon and triethylamine vapor acts as the counting gas while crossed-wire grids operate at 3-4 kV, twice the usual proportional counting voltage. At each decay event, the electron avalanche produces gaseous scintillation; for argon, approximately 35 photons are produced per keV of beta particle energy with the output centered at 280 nm. The photons form a spot that is then viewed by the camera. Not only is that event recorded, but also the particle origin on the monitor in real-time. The Biospace Beta Imager offers a field of view/sample size of 200 mm x 250 mm suitable for whole mouse imaging and 4 levels of zoom. It has exceptional detection thresholds (e.g., 3H 0.007 cpm/mm2; 14C, 35S, 33p 0.01 cpm/mm2; 32p 0.1 cpm/mm2) and spatial resolution (Full-Width at Half Maximum as low as 60 fm for the smallest detectable feature) and a pixel resolution to 10 fm. The efficiency (the ratio of detected particles to number of particles emerging from sample) can be as high as 90% with a linearity of better than 2% over a dynamic range of 104. The instrument is supported by beta VISION +TM software for image analysis with the option for dual-isotope analysis. This proposal from WUSM, is to request funds for a Biospace a Imager to aid in the design and application of drugs and radiopharmaceuticals for the betterment of researchers from a broad range of disciplines, including ontology, neurology, chemistry and pulmonary medicine.