COBRE: UL: ADMIN: ALTERATION & RENOVATION

描述(由申请人提供)：申请生物医学研究卓越中心(COBRE)的目的是促进与健康相关的研究，并提高UL牙科学校出生缺陷中心初级、无资金支持的研究人员对独立资助的竞争力。如果获得资金，该中心将通过提供灵活的支持来扩大和发展生物医学教职人员的研究能力，从而增强和加强出生缺陷中心的生物医学研究能力。该计划由一位知名的生物医学研究科学家领导，他以其对提案研究主题至关重要的广泛专业知识而广为人知。该申请寻求对来自几个互补学科的初级调查人员的支持，每个人都将由一名成熟的、资金充足的高级生物医学研究教员指导，该教员因其在初级调查人员研究提案领域的科学专长而受到认可。这种方法是这一倡议成功的关键保证。这项申请代表了一系列综合研究，重点是两个共同的主题--出生缺陷的分子机制和细胞信号转导--这两个主题涵盖了许多不同的科学学科。来自牙科和医学院三个不同系的教员代表了多种科学学科，提出了一种多功能的方法来解决发育异常的分子基础问题。如果这项申请获得资助，将极大地促进五名年轻调查员的发展，他们具有发展成为有竞争力、独立和合作的调查员的突出潜力。为他们的研究事业发展制定了详细的计划，概述了实现外部支持的期望和目标，向这些初级教师提供的部门和大学支持的程度是机构承诺的重要、明确和有形的证据，并且有足够和足够的空间和设备资源来进行拟议的研究。

DESCRIPTION (provided by applicant): The purpose of this application for a Center of Biomedical Research Excellence (COBRE) is to foster health-related research and increase the competitiveness of junior, unfunded investigators at the Birth Defects Center at the UL School of Dentistry for independent funding. If funded, this COBRE will augment and strengthen the biomedical research capacity at the Birth Defects Center through provision of flexible support to expand and develop biomedical faculty research capability. The program is led by an established biomedical research scientist, well recognized for his extensive expertise central to the research theme of the proposal. The application seeks support for junior investigators from several complementary disciplines, each of whom will be mentored by an established, well-funded senior biomedical research faculty member, recognized for his/her scientific expertise in the area of the junior investigator's research proposal. This approach is a critical assurance of success of this initiative. This application represents an integrated series of studies focusing on two common themes - molecular mechanisms of birth defects and cellular signal transduction - that encompass a number of diverse scientific disciplines. Faculty from three different departments in the Schools of Dentistry and Medicine, representing a multiplicity of scientific disciplines, present a multifunctional approach to questions of the molecular basis of developmental anomalies. This application, if funded, will substantially enhance the development of five young investigators with outstanding potential to develop into competitive, independent and collaborative investigators. A detailed plan for their research career development has been formulated, expectations and goals for achieving extramural support is outlined, the extent of departmental and university support provided to these junior faculty is substantial, clear and tangible evidence of institutional commitment has been documented, and sufficient and adequate space and equipment resources for the conduct of the proposed studies exists.