NSAIDS, POLYAMINE-DEPLETION & DEPOLARIZED MEMBRANE POTENTIAL

描述(由申请者提供)：科布尔奖授予KU兽医学院(CVM)将提供必要的资源，以提升该机构和其他堪萨斯州机构的初级基础研究人员和临床科学家的研究计划，以成功地获得独立的NIH资金。KU CVM以及KU和KUMC合作部门的七个初级教员和导师团队已被确定为有资格发起这一计划。全州范围内的竞争将在该奖项的最后几年确定更多的初级教师和他们的导师。所有已确定的课程都以上皮细胞生理学或病理生理学为中心，并为翻译研究提供了坚实的基础。为了促进项目的成功，将建立3个核心设施：1)最先进的共焦显微镜设施，2)基因阵列分析站和3)上皮电生理学设施。所有的努力和支出将以尽快将初级教员转移到由NIH资助的独立调查人员的水平为最终目标。为此，Cobre的项目负责人将与其他导师和咨询委员会成员一起创建并参与视频会议研讨会和密集的个人L指导中的跨学科互动的结构化计划。行政程序将确保导师和初级教员对其职责领域的问责。通过项目的科学价值、个人研究人员的研究实力、初级和高级教员对指导计划目标的热情承诺以及CVM的比较生物医学研究的加强，可以预测拟议计划的成功。KU CVM的管理层高度支持其研究和临床教员，但科布尔奖将提供资金和结构化计划，以充分实现其有才华的初级教员的“承诺”。

DESCRIPTION (provided by applicant): A COBRE award to the College of Veterinary Medicine (CVM) at KU will provide the resources necessary to elevate the research programs of junior basic researchers and clinician-scientists at this and other Kansas institutions to become successful at obtaining independent NIH funding. Seven teams of junior faculty members and mentors in the KU CVM and collaborating departments at KU and at KUMC have been identified as qualified to initiate this program. Statewide competition will identify additional junior faculty and their mentors in the later years of the award. All of the identified programs center on epithelial cell physiology or pathophysiology and provide a strong foundation for translational research. To enhance programmatic success 3 core facilities will be established: 1) a state-of-the-art confocal microscope facility, 2) gene array analysis station and 3) an epithelial electrophysiology facility. All efforts and expenditures will be guided by the ultimate goal of moving the junior faculty to the level of independent NIH-funded investigator as rapidly as possible. To this end, the project leader of this COBRE along with the other mentors and advisory committee members will create and participate in a structured program of interdisciplinary interactions in video-conferenced seminars and intensive individual l guidance. Accountability of mentors and junior faculty for their areas of responsibility will be assured by the administrative processes. The success of the proposed program is predicted by the scientific merit of the projects, the research strength of the individual investigators, the enthusiastic commitment of junior and senior faculty to the goals of the mentoring program and enhancement of comparative biomedical research at the CVM The administration at the CVM at KU is highly supportive of its research and clinical faculty, but this COBRE award will provide the financial means and the structured program to realize fully the "promise" of its talented junior faculty.