Robust Software Components for Model Organism Databases

描述（由申请人提供）：我们建议进一步开发一套强大的软件组件，用于构建模型生物数据库（MOD）。这些软件组件将支持3种主要类型的操作：创建新的MOD，交互式编辑和管理MOD，以及MOD的Web发布。这3种类型的操作将支持以下生物信息学数据库：基因组图谱、基因、操纵子、启动子、蛋白质、生化反应、代谢和信号传导途径以及小分子代谢物。这些软件组件将基于EcoCyc数据库的Pathway Tools软件和其他MOD。Pathway Tools是一个成熟、复杂、生产质量的软件环境，已获得60个团队的许可，这些团队已经构建了20个现有的MOD，并计划构建20多个其他MOD。我们还建议为Pathway Tools的大型和不断增长的用户社区提供支持服务，维护软件的高质量文档，并每年创建2个经过彻底测试的软件版本。我们还将与其他MOD软件组件的开发人员社区进行互动，以确保我们的软件组件与其他团体开发的组件的互操作性。

DESCRIPTION (provided by applicant): We propose to further develop a set of robust software components for constructing model-organism databases (MODs). Those software components will support 3 main types of operations: creation of new MODs, interactive editing and curation of MODs, and Web publishing of MODs. Those 3 types of operations will be supported for the following bioinformatics datatypes: genome maps, genes, operons, promoters, proteins, biochemical reactions, metabolic and signaling pathways, and small-molecule metabolites. These software components will be based on the Pathway Tools software that underlies the EcoCyc database, and other MODs. Pathway Tools is a mature, sophisticated, production-quality software environment that has been licensed by 60 groups who have constructed 20 existing MODs and plan to construct more than 20 additional MODs. We further propose to provide support services for the large and growing user community for the Pathway Tools, to maintain quality documentation for the software, and to create 2 thoroughly tested releases of the software per year. We will also interact with the community of developers of other MOD software components to ensure interoperability of our software components with components developed by other groups.