LSUHSC COBRE:POLYAMINE METABOLISM IN EBV LYMPHOMAGENESIS

描述(由申请人提供)： 根据NIH IDEA计划提交的这项提案的目的是通过建立生物医学研究卓越中心(COBRE)：分子和肿瘤病毒学中心，促进路易斯安那州立大学健康科学中心(LSUHSC)在研究竞争力和基础设施方面的可持续改善。四名在分子、肿瘤和免疫病毒学领域工作的资深病毒学家将担任五名初级教员(一名将于第二年招聘)的导师，以增强他们对国家资金的竞争力，并提高他们正在开发的研究计划的生产率。提出了一项详细的计划，以指导这些初级调查人员与明确的标准，以评估其研究计划的发展和竞争力。该计划强调导师和初级教员研究人员的密切互动，并将创建一个细胞培养和分子分析核心设施，以补充LSUHSC研究核心设施的最先进服务。此外，一个由国际公认的病毒学家组成的外部咨询委员会将担任分子和肿瘤病毒学中心的审查员，该委员会由国际公认的病毒学家组成，其中四人是国家科学院成员，以监督和同行审查正在进行的研究项目，并提出有助于该中心卓有成效的建议。该中心是多学科的，因为初级教员的项目与部门正在进行的研究相联系。医学(病毒疾病)和生理学(内皮细胞改变)和我们的癌症(肿瘤病毒学)和关节炎(炎症)中心，并解决病毒感染导致的不同疾病状态的机制。这些疾病包括疱疹病毒引起的严重炎症性疾病、巨细胞病毒引起的内皮细胞改变导致心血管疾病、黄热病的分子发病机制以及多胺代谢在EB病毒淋巴瘤形成中的作用。该中心有一个主题科学重点，即应用于这些疾病状态模型的分子方法试图阐明病毒基因产品改变细胞和协调导致疾病的事件的各种方法。这四名私家侦探都在博士和博士后水平上接受过良好的分子病毒学培训，并将获得空间、资源和释放的时间来开发具有国家资金竞争力的最先进的研究项目。

DESCRIPTION (provided by applicant): The purpose of this proposal submitted under the NIH IDEA Program is to promote sustainable improvements in research competitiveness and infrastructure at the LSU Health Sciences Center (LSUHSC) by establishing the Center of Biomedical Research Excellence (COBRE): Center for Molecular and Tumor Virology. Four senior virologists working in molecular, tumor, and immunological virology will serve as mentors to five junior level faculty members (one to be recruited in Year 2) to enhance their competitiveness for national funding and to increase the productivity of their developing research programs. A detailed plan to mentor these junior investigators with well-defined criteria to assess the development and competitiveness of their research programs is presented. The plan stresses close interaction of the mentors and junior faculty investigators and will create a Cell Culture and Molecular Analysis Core Facility that will complement the state-of-the-art services of the LSUHSC Research Core Facilities. In addition, an External Advisory Committee comprised of internationally recognized virologists, four being members of the National Academy of Sciences, will serve as reviewers of the Center for Molecular and Tumor Virology to provide oversight and peer review of the ongoing research projects and to offer suggestions that would contribute to the excellence of the Center. The Center is multidisciplinary as the projects of the junior faculty P.l.s interface with ongoing research in the Depts. of Medicine (viral diseases) and Physiology (altered endothelium) and our Cancer (tumor virology) and Arthritis (inflammation) Centers and address the mechanisms of different disease states resulting from viral infection. These diseases include herpesvirus induced severe inflammatory disease, cytomegalovirus induced alterations in endothelial cells leading to cardiovascular disease, molecular pathogenesis of yellow fever, and the role of polyamine metabolism in Epstein Barr virus lymphomagenesis. The Center has a thematic scientific focus in that molecular approaches applied to models of these disease states seek to elucidate the varied means by which viral gene products alter the cell and orchestrate events that result in disease. All four P.I.s are well trained in molecular virology at the doctoral and postdoctoral levels and will be provided the space, resources, and released time to develop state-of-the-art research programs competitive for national funding.