Temperature-activated TRP channels and thermosensation

近年来在感觉神经生物学的分子描述方面取得了很大进展。在五种常见的感官--视觉、听觉、味觉、嗅觉和触觉--中，触觉是变化最大的，也是人们最不了解的。在这种形态中， 机械力、化学刺激和温度，以及介导这种能力的分子 一直是个谜我的团队和其他人最近发现了离子通道 它们被不同的温度阈值激活，可能使感觉神经元能够 传递温度信息。在这些离子通道中有TRPV 3， 温度，并在皮肤中表达。在这里，我们使用遗传和生物化学工具来测试， TRPV 3及其同源物在热感觉和疼痛中起重要作用。

Recent years have seen great advances in the molecular description of sensory neurobiology. Of the five popularly characterized senses - sight, hearing, taste, smeli, and touch - touch is among the most varied and perhaps least understood. Within this modality is the ability to sense mechanical forces, chemical stimuli, and temperature, and the molecules that mediate this ability have been a long-standing mystery. My group and others have recently discovered ion channels that are activated by different thresholds of temperature, and might enable sensory neurons to convey temperature information. Among these ion channels is TRPV3, which senses warm temperatures and is expressed in the skin. Here we use genetic and biochemical tools to test if TRPV3 and its close homologs play an essential role in thermosensation and pain.