Gene Expression Signature Technology to Repurpose Drugs for Bipolar Disorder
Gene Expression Signature Technology to Repurpose Drugs for Bipolar Disorder
批准号:
nhmrc : 1078928
负责人:
Prof Brian Dean
金额:
$32.19万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
在这个项目中,我们将生成一个基因表达签名,最好地表征目前用于治疗双相情感障碍的鸡尾酒药物的整体生物学效应。Signature将在细胞和完整的大脑中进行鉴定,然后使用人类基因表达谱进行验证。经过验证的签名将用于筛选文库并发现治疗双相情感障碍的新药。
英文摘要
In this project we will generate a Gene Expression Signature that best characterises the overall biological effects of a cocktail of drugs currently used to treat bipolar disorder. The Signature will be identified in cells and intact brains, and then validated using human gene expression profiling. The validated Signature will then be used to screen libraries and discover new drugs for treating bipolar disorder.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Understanding the pathophysiology of schizophrenia, major depressive disorder and bipolar disorder as a basis for improving treatments
-
批准号:nhmrc : 1002240
-
项目类别:Research Fellowships
-
资助金额:$53.62万
-
财政年份:2011
-
负责人:Prof Brian Dean
-
依托单位:
Understanding the Role of Muscarinic Receptors in the Pathophysiology of Depression and Bipolar Disorder
-
批准号:nhmrc : 628669
-
项目类别:NHMRC Project Grants
-
资助金额:$32.01万
-
财政年份:2010
-
负责人:Prof Brian Dean
-
依托单位:
Research Fellowship - Grant ID:400016
-
批准号:nhmrc : 400016
-
项目类别:NHMRC Research Fellowships
-
资助金额:$40.48万
-
财政年份:2006
-
负责人:Prof Brian Dean
-
依托单位:
A Study of Muscarinic Receptors in Brain Tissue Obtained Postmortem from Subjects with Schizophrenia
-
批准号:nhmrc : 209046
-
项目类别:NHMRC Project Grants
-
资助金额:$23.66万
-
财政年份:2002
-
负责人:Prof Brian Dean
-
依托单位:
THE ROLE OF CHANGES IN THE HIPPOCAMPAL SEROTONIN TRANSPORTER IN THE PATHOLOGY OF SCHIZOPHRENIA
-
批准号:nhmrc : 114253
-
项目类别:NHMRC Project Grants
-
资助金额:$22.69万
-
财政年份:2000
-
负责人:Prof Brian Dean
-
依托单位:
国内基金
海外基金
HarpinXoo 启动水稻抗病性及相关信号传导调控基因的表达图式 (expression profiles)
-
批准号:30370969
-
项目类别:面上项目
-
资助金额:17.0万元
-
批准年份:2003
-
负责人:董汉松
-
依托单位: