Phase I/II Partnership in Biomedical Discovery

描述(由申请人提供)： 这一第一阶段/第二阶段项目的总体目标是，通过向高中教师和学生介绍以探究为基础的过程，即科学研究，开发研究型大学的科学专长如何直接影响当地K-12科学教育的模式。我们的基本前提是，真正的科学知识需要积极参与科学探究，这样从事的教师和学生可以成为科学教育变革的推动者。为此，我们建议选定的生物教师和高中生沉浸在为期8周的暑期研究体验中，在此期间，他们直接参与大学环境中的前沿研究。在九个大学研究实验室的参与和指导下，一个实验室的师生团队将使用三组模式生物：细菌、酵母和线虫，对新的突变进行基因筛查。尽管这些研究实验室有不同的目标，采用了不同的实验方法和不同的技术，但有一个共同点，那就是它们使用遗传学的方法和范式来研究公众感兴趣和关注的与健康有关的问题。与会教师、教师咨询委员会和大学教职员工每周举行一次课程圆桌会议，重点是根据这些模式生物开发探究式教育模块和实验包，供高中和中学课堂使用，并讨论评估此类模块影响的方法和机制。这些单元将在项目第2至第5年为高中教师(没有进行研究经验的人)举办的为期一周的课程讲习班上进行测试、改进和传播。在接下来的几年里，我们将为高中班级提供实验套件，通过我们的课程的老师可以实施探究式课程模块。项目评估的目的是比较参加过为期8周研究的教师和参加过为期一周的课程研讨会的教师在采用和有效使用基于探究的方法和模块方面的情况，以跟踪学生参与者的教育和职业道路，并评估对高中生物学习的影响。

DESCRIPTION (provided by applicant): The overall objective of this phase I/II project is to develop a model of how the scientific expertise of a research university can directly impact local K-12 science education, by introducing high school teachers and students to the inquiry-based process that is scientific research. Our fundamental premises are that true science knowledge requires active engagement in scientific inquiry, and that teachers and students so engaged can become agents of change in science education. To this end, we propose to immerse selected biology teachers and high school students in an 8-week summer Research Experience, during which they participate directly in cutting-edge research in a University environment. With the participation and guidance of nine University research labs, teacher-student teams in a single lab facility will perform genetic screens for new mutations using three sets of model organisms: bacteria, yeast and C. elegans. Although these research labs have diverse objectives and employ varied experimental approaches and different techniques, there is a common thread in that they use the methods and paradigms of genetics to study health-related problems of interest and concern to the public. Weekly Curriculum Roundtable meetings among participating teachers, a Teacher Advisory Board and University faculty will focus on developing inquiry-based education modules and experiment kits, based on these model organisms, for use in high school and middle-school classrooms, and on methods and mechanisms for assessing the impact of such modules. The modules will be tested, refined and disseminated in one-week Curricular Workshops for high school teachers (who have not done the Research Experience) in project years 2-5. During succeeding years, we will provide experiment Kits for high school classes, with which teachers who have been through our programs can implement the inquiry-based curricular modules. Project evaluations aim to compare teachers who have done the 8-week Research Experience with those who have done the one-week Curricular Workshop, with respect to adoption and effective use of the inquiry-based methods and modules, to track educational and career paths of student participants, and to assess the impact on learning in high school biology.