Cortical Planning and Control of Smooth Pursuit

描述(申请人提供)：平滑追逐是一种自愿的眼球运动，用于在物体移动时观察它们。虽然生理学家已经研究了自主眼跳控制的许多方面，但大多数关于追逐的神经控制的工作都将这个系统视为对视网膜图像运动的反射性反应。灵长类动物的追逐系统是一种复杂的眼球运动系统，它已经进化到可以预测物体移动的时间和地点，并决定是否追逐该物体。目前授权期的重点是了解皮质眼场如何合作控制自愿顺畅的眼球运动。目标是： 1.比较皮层眼场用于执行追逐眼动的预测信号和视网膜图像信号的强度 2.确定皮层眼场如何相互作用以取消追逐运动。 3.确定如何决定执行或取消追逐移动。 这些实验的结果应该有助于我们了解大脑皮质如何移动眼睛，以便有效地查看自然场景中的移动对象。这项工作的结果将为斜视和弱视等视力障碍的诊断和治疗提供基础数据，并开发假体设备来帮助患有这些疾病的人。

DESCRIPTION (provided by applicant): Smooth pursuit is a voluntary eye movement that is used to view objects as they move. Although physiologists have studied many aspects of voluntary saccade control, most work on the neural control of pursuit has treated this system as if it responds reflexively to retinal-image motion. The pursuit system of primates is a sophisticated ocular movement system that has evolved to allow it to predict when and where an object will move, and to decide whether or not to pursue that object. The focus of the current grant period is to understand how the cortical eye fields cooperate to control voluntary smooth pursuit eye movements. Aims are to: 1. Compare the strength of predictive and retinal-image signals used by the cortical eye fields to execute a pursuit eye movement 2. Determine how the cortical eye fields interact to cancel a pursuit movement. 3. Determine how the decision is made to execute or cancel a pursuit movement. The results of these experiments should contribute to our knowledge of how the cortex moves the eyes to effectively view moving objects in the natural scene. The results of this work should provide basic data to facilitate diagnosis and treatment of disorders of vision such as strabismus and amblyopia, and to develop prosthetic devices to aid people who suffer from these disorders.