Botanical Dietary Supplements for Women's Health

UIC/NIH植物性膳食补充剂研究中心成立于1999年秋季，旨在解决植物性膳食补充剂的标准化、质量、安全性和有效性问题。该中心随后采用并将继续实施多学科战略，以实现其基础和临床研究目标。参与研究的院系合作研究员和合作者来自药学院的药物化学、生药学和生物制药科学系；医学院的医学系(内分泌和新陈代谢学部)；以及文学院的数学、统计和计算机科学系。该中心研究对女性健康有潜在好处的植物，重点是据报道可以缓解更年期和经前综合症症状的植物。植物提取物要经过严格的化学评估，然后进行体外和体内生物测试。标准化植物学 在体外和动物模型中，似乎有效并表现出足够安全性的提取物将成为临床I期试验的候选药物。啤酒花(Humulus lupulus L.)将在本赠款周期中进行第一阶段评估。为了实现开发化学和生物标准化植物膳食补充剂的全面议程，更新的BRC研究方案将围绕三个项目组织，并得到两个核心的支持：Farnsworth的项目，植物性药物的标准化；Bolton的项目， 植物的作用(更年期)；范·布里曼的项目，新陈代谢、生物利用度和毒性的研究；管理和开发核心和分析核心。行政和发展核心将管理另外两个方案：一个试点项目方案和一个培训和职业发展方案。这项研究中提出的实验 应用将大大提高我们对植物性药物的作用机理以及它们对妇女健康是否安全有效的了解。

The UIC/NIH Center for Botanical Dietary Supplements Research was established in the fall of 1999 to address the issues of standardization, quality, safety, and efficacy of botanical dietary supplements. The Center then adopted and will continue to implement a multidisciplinary strategy to achieve its basic and clinical research objectives. Participating faculty Co-investigators and collaborators are drawn from the Departments of Medicinal Chemistry and Pharmacognosy and Biopharmaceutical Sciences in the College of Pharmacy; the Department of Medicine (Section of Endocrinology and Metabolism) in the College of Medicine; and the Department of Math, Statistics, and Computer Science in the College of Liberal Arts. The Center studies botanicals with potential benefits for women's health, focusing on plants that are reported to alleviate the symptoms of menopause and premenstrual syndrome. Botanical extracts are subjected to rigorous chemical evaluation followed by both in vitro and in vivo biological testing. Standardized botanical extracts that appear efficacious and demonstrate adequate safety profiles in in vitro and animal models will be candidates for clinical, Phase I trials. Hops (Humulus lupulus L.) will undergo Phase I evaluation in this grant cycle. In order to achieve this comprehensive agenda for the development of chemically- and biologically-standardized botanical dietary supplements, the renewed BRC research program will be organized around three Projects, supported by two Cores: Project by Farnsworth, Standardization of Botanicals; Project by Bolton, Mechanism of Action of Botanicals (Menopause); Project by van Breemen, Studies of Metabolism, Bioavailability, and Toxicity; Administration and Development Core and Analytical Core. The administration and Development Core will administer two additional programs: a Pilot Project Program and a Training and Career Development Program. The experiments proposed in this application will greatly enhance our understanding of the mechanism of action of botanicals and whether they are safe and efficacious for women's health.