IMAGING METHODS FOR IMAGE GUIDED THERAPY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该项目的总体目标是利用射频激发和射频灵敏度曲线的灵活性来开发混合成像序列，并使这些方法可作为增强mri引导治疗应用的资源，特别是基于mri的热疗法监测。我们实现这一目标的具体目标是：(1)将非傅立叶和射频编码与标准傅立叶编码MRI方法相结合，开发用于图像引导治疗的混合成像序列。(2)开发具有运动鲁棒性的单镜头自旋回波线扫描和具有多重对比度的平板扫描序列，用于图像引导治疗；(3)开发适合图像引导治疗需求的各种并行成像实现。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The general goal of this project is to exploit the flexibility of RF excitation and RF sensitivity profiles for the development of hybrid imaging sequences and, to make these methods available as a resource for enhancing MRI-guided therapy applications, in particular, MRI-based monitoring of thermal therapies. Our specific aims to achieve this goal are: (1) To develop hybrid imaging sequences for image-guided therapy combining non-Fourier and RF encoding with standard Fourier-encoded MRI methods. (2) To develop motion-robust, single-shot spin-echo line-scan and slab-scan sequences with multiple contrasts for image-guided therapy, (3) To develop a variety of parallel imaging implementations tailored to the needs of image-guided therapy.