Clinical Core

临床核心C的目标是： 1.为招募和表征正常和哮喘患者提供中心实验室 项目1、2和3的临床部分的受试者。 2.为肺功能检测的性能和质量控制提供中心设施，抗原 皮试和乙酰甲胆碱激发试验 3.提供一个中心实验室，用于收集和分析支气管肺泡灌洗液和活检 组织. 4.协调支气管肺泡灌洗液细胞和液体以及活检组织的分布， 项目1、2和3的研究人员。 5.协调正常受试者的所有临床和实验室数据的数据库开发， 哮喘患者以及将数据传输给个体研究者。 6.促进项目间关于临床发现和技术 成就。 在这样做的过程中，该计划项目补助金的临床方面将以高标准运作。

The objectives of the Clinical Core C are: 1. To provide a central laboratory for the recruitment and characterization of normal and asthmatic subjects for the clinical components of Projects 1, 2, and 3. 2. To provide a central facility for performance and quality control of pulmonary function testing, antigen skin testing, and methacholine challenge. 3. To provide a central laboratory for collection and analysis of bronchoalveolar lavage fluid and biopsy tissue. 4. To coordinate the distribution of bronchoalveolar lavage cells and fluid, and biopsy tissue to the investigators in Projects 1, 2, and 3. 5. To coordinate the database development of all clinical and laboratory data on normal subjects and patients with asthma as well as transmittal of the data to the individual investigators. 6. To facilitate interproject communication concerning both clinical findings and technical accomplishments. In doing so, the clinical aspects of this Program Project grant will function at a high standard.