ELECTRON MICROSCOPE: NANOTECHNOLOGY, CANCER

这个子项目是利用由NIH/NCRR资助的共享仪器赠款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是用于拨款的，而不一定是用于调查人员的机构。描述(由申请人提供)：密苏里大学电子显微镜核心设施为密苏里大学校园内的研究提供唯一的电子显微镜服务和仪器。正是通过这个核心设施，主要用户群体进行了需要透射电子显微镜的研究。目前在核心设施中的透射电子显微镜是大约20年前购买的。我们已接到制造商的通知，这种仪器不再有新的替换部件可供使用。仪器继续使用二手部件进行维修，但一旦任何关键部件的供应耗尽，仪器可能很快就会失去功能。此外，现有显微镜没有一些用户组需要的新仪器上可用的功能。这项应用的目标是用现代的瞬变电磁法取代旧的仪器，这种瞬变电磁法可以配备能够满足主要用户群体和其他NIH资助的研究人员在未来15到20年内的研究需求的功能。核心中使用的绝大多数透射电子显微镜是由NIH资助的研究。电子显微镜核心服务目前用于支持糖尿病、衰老、心血管疾病、营养、神经退行性疾病和各种其他健康问题的研究。目前安置在核心中的瞬变电磁波将不能再进行维修的时间即将到来。在缺乏可靠的替换部件供应的情况下，完全失去瞬变电磁能力的风险很高。所需的瞬变电磁波将设在现有的核心设施内，并由经验丰富的核心工作人员进行维护。核心工作人员将在电子显微镜服务学院协调员的指导下，与用户咨询委员会协商，监督仪器的使用。仪器使用方面的培训将由核心员工和相关教员提供。工作人员的工资将继续由使用费和大学经费提供。将与制造商签订服务合同，为核心员工无法履行的仪器提供服务。服务合同费用将由使用费和必要时的机构补贴来支付。该工具将以适用于主要用户群体的基本相同条款向主要用户群体以外的用户提供。扩大用户基础将有助于使维护仪器的每个用户的成本尽可能低。

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The University of Missouri Electron Microscopy Core facility provides the only electron microscopy services and instrumentation for research on the University of Missouri campus. It is through this Core Facility that the major user group performs research that requires transmission electron microscopy. The transmission electron microscope (TEM) currently in the Core Facility was acquired approximately 20 years ago. We have been informed by the manufacturer that new replacement parts are no longer available for this instrument. The instrument continues to be serviced with used parts, but once the supply of any critical part is exhausted, the instrument could soon become nonfunctional. In addition, the existing microscope does not have some features available on newer instruments that are needed by the user group. The objective of this application is to replace the old instrument with a modern TEM that can be equipped with features that will meet the research needs of the major user group and other NIH-funded investigators over the coming 15 to 20 years. The great majority of TEM use in the Core is for NIH-funded research. Core TEM services are currently used to support research on diabetes, aging, cardiovascular disease, nutrition, neurodegenerative disorders, and a variety of other health problems. The time is near when the TEM presently housed in the Core will no longer be able to be serviced. In the absence of a reliable supply of replacement parts, the risk of losing TEM capability altogether is high. The requested TEM will be housed in the existing Core Facility and will be maintained by experienced Core staff. Core staff will supervise use of the instrument under the direction of a Faculty Coordinator for Electron Microscopy Services in consultation with a user Advisory Committee. Training in instrument use will be provided by Core staff and associated faculty. Staff salaries will continue to be provided from a combination of user fees and University funds. A service contract will be maintained with the manufacturer to provide service for the instrument that cannot be performed by Core staff. Service contract costs will be covered by user fees and an institutional subsidy if necessary. The instrument will be available to users outside of the major user group under essentially the same terms that apply to major user group. Broadening the user base will help make the cost per user of maintaining the instrument as low as possible.