Comparative Toxicogenomics Database (CTD)

描述（由申请人提供）：本提案的目标是建立一个权威的公共数据库，即比较毒理基因组学数据库（CTD; http://ctd.mdibl.org），以促进对环境化学品对人类健康影响的了解。大多数慢性疾病的病因涉及环境和遗传因素之间的相互作用。尽管目前商业上使用的化学品超过85，000种，但人们对大多数化学品的作用及其对人类健康的影响的复杂分子机制知之甚少。在CTD中，我们将介绍有关环境化学物质，重要基因及其在脊椎动物和无脊椎动物中相互作用的科学审查信息。该提案的具体目标是：1）从已发表的文献和高通量实验数据（例如，微阵列）; 2）策划跨物种毒理学重要基因及其蛋白质; 3）将CTD原型转化为一个强大的生产质量数据库，以增加公众使用和更复杂的数据搜索和分析能力。CTD将是第一个专注于化学基因相互作用和不同物种中毒理学意义基因的数据库，以阐明结构-功能相关性。这些数据将是建立化学作用网络模型的关键，并为环境诱导的毒性和疾病的易感性差异提供重要的见解。CTD的见解也将对毒性预测和环境监管产生重要影响。我们正在开发公开的比较毒理基因组学数据库（CTD），以促进对环境化学品对人类健康影响的了解。CTD将提供关于重要化学品、基因及其在脊椎动物和无脊椎动物中相互作用的信息。这些数据将为深入了解化学作用的机制以及生物体和个体之间不同毒性的遗传基础提供重要见解，并将对毒性预测和环境监管产生重要影响。

DESCRIPTION (provided by applicant): The goal of this proposal is to establish an authoritative public database, the Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org), that promotes understanding about the effects of environmental chemicals on human health. The etiology of most chronic diseases involves interactions between environmental and genetic factors. Although more than 85,000 chemicals are used in commerce today, the complex molecular mechanisms underlying the actions of most of these chemicals and their effects on human health are poorly understood. In CTD we will present scientifically reviewed information on environmental chemicals, significant genes, and their interactions in vertebrates and invertebrates. The specific aims of this proposal are to: 1) curate and integrate chemical-gene interactions from published literature and high-throughput experimental data (e.g., microarrays); 2) curate cross-species toxicologically important genes and their proteins; and 3) transform the CTD prototype into a robust, production-quality database ready for increased public use and more sophisticated data search and analysis capabilities. CTD will be the first database to focus its curation on chemical-gene interactions and genes of toxicological significance in diverse species to elucidate structure-function correlations. These data will be key to building network models of chemical actions and providing important insights into differences in susceptibility to environmentally-induced toxicity and disease. Insights from CTD will also have important implications for toxicity prediction and environmental regulation. We are developing the publicly available Comparative Toxicogenomics Database (CTD) to promote understanding about the effects of environmental chemicals on human health. CTD will provide information on significant chemicals, genes, and their interactions in vertebrates and invertebrates. These data will provide important insights into the mechanisms of chemical actions and the genetic basis of differential toxicity among organisms and individuals, and will also have important implications for toxicity prediction and environmental regulation.