Generation of protective immunity against severe influenza disease in Indigenous Australians

在土著人口中，流感的住院率和死亡率很高，特别是在出现新病毒的时候。目前迫切需要一种能够预防所有流感病毒株的疫苗。识别保守病毒区域的T细胞可以获得这种保护。由于T细胞受到被称为HLA的蛋白质的限制，这种蛋白质因种族而异，我们将为土著澳大利亚人中突出的HLA定义T细胞区域，并定义如何产生针对流感的保护性免疫。

Hospitalisation and death rates from influenza are high in the Indigenous population, especially when a new virus emerges. There is an urgent need for a vaccine that protects against all influenza strains. T cells recognising conserved viral regions elicit such protection. As T cells are restricted by proteins called HLAs, which vary across ethnicities, we will define T cell regions for HLAs prominent in Indigenous Australians and define how to generate protective immunity against influenza.