The Quantification of Orthotic interventions in Osteoarthritic Knee Instability (QOOKI)

项目描述本项目旨在开发和验证一种明确、客观的测量方法来量化和诊断膝关节不稳定，该方法可以在临床中轻松收集。我们认为惯性测量单元（IMU）技术在这种情况下是最合适的。我们将重点关注OA人群，因为这一人群普遍存在不稳定性，但其目的是更广泛地应用于其他健康和TKA膝关节。为了达到上述目标，我们将使用软膝支架和卸载膝支架来影响膝关节运动学，以验证客观测量并确定每种类型的支架的有效性。在此过程中，我们将识别那些最有可能从矫形干预中获益的膝关节特征。我们还旨在解决关于个人主观不稳定性是否有机械或本体感觉缺陷引起的争论，通过适当调整支架，使参与者聚类和分类到不同的组（即机械或神经）基于我们开发的测量。

Project DescriptionThis project aims to develop and validate an unambiguous, objective measure to quantify and diagnose knee instability which can easily be collected in the clinic. We believe inertial measurement unit (IMU) technology to be most appropriate in this context. We shall focus on the OA population due to the prevalence of instability in this population, but the aim has a wider application to both otherwise healthy and TKA knees. To achieve the above aim, we shall affect knee kinematics using both soft and unloading knee braces to both validate the objective measure and to ascertain the effectiveness of each type of brace. In doing so, we will identify the characteristic knee signatures of those most likely to benefit from orthotic intervention. We also aim to disentangle the debate regarding whether an individual's subjective instability has a mechanical or proprioceptive-deficit cause by suitable adjustment of the braces enabling the clustering and categorising of participants into different groups (i.e. mechanical or neurological) based on our developed measure.