How does knee joint and meniscal tissue shape affect joint biomechanics and treatment choice?

英国有超过450万人患有膝关节炎。膝关节中央的半月板组织受损，既可能是膝骨性关节炎的原因，也可能是其症状。然而，成功的治疗仍然难以捉摸，部分原因是膝关节解剖和功能的差异。这个博士学位将建立在利兹大学开发的新的实验和计算方法的基础上，以研究半月板修复或替代手术如何更好地匹配患者的特征。方法将包括：生理相关条件下关节的有限元建模；探索膝关节功能如何随着骨骼和半月板形状的变化而变化的统计形状建模；以及半月板组织和同种异体移植物的实验评估。目的和目的本博士的目的是研究半月板修复或置换手术如何更好地与患者的特征相匹配。采用实验和计算相结合的方法，目的是：-使用成像和体外测试方法来表征半月板组织的形状和特性的变化-使用基于图像的自然膝关节的有限元模型来检查这些变化如何影响膝关节运动学-探索使用统计形状和外观模型来表示总体的变化，并检查半月板手术恢复个人生物力学功能所需的匹配

Over 4.5 million people in the UK have knee arthritis. Damage to the meniscus tissue, at the centre of the knee joint, can be both a cause and symptom of knee osteoarthritis. However, successful treatment remains elusive, partly due to variations in knee anatomy and function. This PhD will build on the novel experimental and computational methods developed at the University of Leeds to examine how meniscal repair or replacement surgery can be better matched to patient characteristics. Methods will include: finite element modelling of the joint under physiologically relevant conditions; statistical shape modelling to explore how knee function alters with variations in bone and meniscus shape; and experimental evaluation of meniscal tissue and allografts. Aim and objectives The aim of this PhD is to examine how meniscal repair or replacement surgery can be better matched to patient characteristics. Using a combination of experimental and computational methods, the objectives are: -To characterize the changes in shape and properties of meniscal tissue using imaging and in vitro testing methods -To examine how these changes affect knee kinematics using image-based finite element models of the natural knee -To explore the use of statistical shape and appearance models to represent variations in the population and examine the match required for meniscal surgery to restore individual biomechanical function