Development of Novel Enzymes for Improvement in Home Care Products and Fragrances

学生将参与发现新的酶，在常温下改善皮脂污渍的去除，并在洗涤过程中原位产生香味分子。埃克塞特集团有与联合利华合作开发适用于不同医疗保健应用的新酶类的历史。该项目将涉及对感兴趣基因的生物信息学鉴定以及它们的克隆和过度表达。它将包括选定酶的生化和结构特征，以及评估它们在洗涤剂配方中的稳定性和在洗涤研究中的有效性。微流控技术还将用于通过荧光底物的快速筛选，快速产生选定酶的改进变体。

The student will be involved in the discovery of novel enzymes for improved sebum stain removal at ambient temperatures and for in-situ generation of fragrance molecules in the wash. The Exeter group has a history of working with the development of new enzyme classes for different healthcare applications together with Unilever. The project will involve bioinformatic identification of genes of interest and their cloning and over-expression. It will include the biochemical and structural characterisation of selected enzymes and assessment of their stability in detergent formulation and effectiveness in wash studies. Microfluidics will also be used for rapid generation of improved variants of selected enzymes using rapid screening with fluorescent substrates.