Exploring the overlap between neurodevelopmental disorders and traits with adolescent hypomania

双相情感障碍（BD）被认为是一种高度遗传性的慢性精神疾病，也是世界范围内致残的主要原因之一，30-50%的患者，即使无症状，也面临社会心理功能障碍。研究表明，在童年时期出现神经发育障碍症状的个体，如自闭症和注意力缺陷多动障碍（ADHD），以及后来在青春期出现轻躁狂特征，可能构成了发展双相障碍病理的有利基础。因此，从科学和实践上发现是什么触发了双相障碍在这些发育途径中的出现，以及所有这些疾病是如何重叠的，将是有益的。本博士旨在发现双相障碍的早期危险因素，以便在疾病发病和进展之前进行适当的干预。，利用这些发展轨迹。

Bipolar disorder (BD) is considered a highly heritable chronic psychiatric disease and one of the leading causes of disability worldwide, with 30-50% of the patients, even when asymptomatic, facing psychosocial functioning impairments.Research suggests that individuals which develop in their childhood symptoms of neurodevelopmental disorders like autism and attention deficit hyperactivity disorder (ADHD) and later in adolescence hypomania traits, may constitute a favorable ground for developing BD's pathology. So, it will be beneficial both scientifically and practically to find what triggers the arrival of BD in these developmental pathways and how all these disorders overlap. This PhD aims to detect early risk factors of BD in order tofacilitate an appropriate intervention before this disease' onset and towards its progression., using these developmental trajectories.