Early Alcohol Use Onset: Influence of Religion-Spirituality Dimensions

描述（由申请人提供）：目的：增加对酒精使用的调节影响的知识，特别是宗教精神（R/S）维度以及对酒精发作和进展的R/S调节的潜在遗传和环境影响。在当前病因学模型的指导下，分析还将研究R/S对酒精使用障碍遗传风险的假设介质的影响：行为控制不足和负面影响调节。目的：（1）R/S维度和R/S-酒精使用关联的表征;（2）使用全表型模型表征R/S维度对早发性和重度酒精使用的主要和交互作用;（3）遗传、共享、和非共享的环境贡献的方差和协方差的R/S尺寸和他们的相关性与年龄在-（4）检验R/S维度在调节基因或共享环境对饮酒起始年龄和饮酒重度的影响中的作用，并描述调节（基因型×环境）效应的特征。方法：次要数据分析将对来自一项大规模前瞻性研究的现有去识别数据进行，该研究涉及物质使用发作和进展以及来自密苏里州出生的青少年女性双胞胎及其家庭先前评估的相关精神疾病。可用的R/S变量将允许检查五个R/S维度在两个关键模型的酒精中毒病因学的调节作用。相关性：由此产生的结果将是相当重要的（a）病因学的努力，在酒精中毒风险的介质和调节剂的特点，（B）治疗和预防的努力，经常观察到的治疗增强和保护作用的R/S对酒精中毒的结果。

DESCRIPTION (provided by applicant): Objective: To increase knowledge of moderating influences on alcohol use, specifically, religious-spiritual (R/S) dimensions and underlying genetic and environmental effects on R/S moderation of alcohol onset and progression. Guided by current etiological models, analyses will also examine R/S effects on the hypothesized mediators of genetic risk for alcohol use disorders: behavioral undercontrol and negative affect regulation. Aims: (1) characterization of R/S dimensionality and R/S-alcohol use association; (2) characterization, using full phenotypic models, of main and interactive effects of R/S dimensions on early onset and heavy alcohol use; (3) estimation of genetic, shared, and non-shared environmental contributions to the variance and covariance of R/S dimensions and to their correlations with age-at-onset of alcohol use and heaviness of alcohol use; (4) to test the role of R/S dimensions in moderating genetic or shared environmental effects on age-at-onset of alcohol use and heaviness of alcohol use, and to characterize moderating (genotype x environment) effects. Method: Secondary data analyses will be conducted on existing, deidentified data from a large-scale prospective research study of substance use onset and progression and associated psychiatric disorders from previous assessments of Missouri-born adolescent female twins and their families. Available R/S variables will permit examination of the moderating effects of five R/S dimensions within two key models of alcoholism etiology. Relevance: Resultant findings will be of considerable importance to (a) etiological efforts in characterizing the mediators and moderators of alcoholism risk, and to (b) treatment and prevention efforts that have frequently observed treatment enhancing and protective effects of R/S on alcoholism outcomes.