Development of a Multi-sample Solids NMR Probe

描述（由申请人提供）：本申请的目的是使固态NMR系统能够更有效和更经济地用于医疗保健研究。固态NMR光谱是分析药物和生物化合物（如蛋白质）的重要工具，但由于收集数据所需的时间较长，因此通常不使用。具体目标是设计和商业化的多样品固体（MSS）探头能够同时分析多达六个样品。在第一阶段，现有的MSS设计概念是由革命核磁共振和堪萨斯大学在200 - 400兆赫范围内的操作，利用革命的经验和能力，在探头设计。在第二阶段，这种设计将得到加强，使探头将能够执行大多数目前的固体核磁共振实验套件，包括三重共振能力。此外，MSS设计将进行修改，以用于高频（高达900 MHz）以及中小口径磁体尺寸。固态核磁共振（NMR）是分析新药和生物分子的一种非常强大的工具，但它的使用往往受到某些实验可能需要数天或数周的事实的限制。该项目将提供一种新的工具，允许同时分析多达六个样品。制药公司、政府实验室和大学将能够在新疗法的开发中更经济有效地利用他们的核磁共振系统

DESCRIPTION (provided by applicant): The objective of this application is to enable more efficient and cost-effective utilization of solid-state NMR systems for health care research. Solid-state NMR spectroscopy is an important tool for the analysis of pharmaceuticals and biological compounds such as proteins, but is often not used due to the length of time required to collect data. The specific aim is to design and commercialize a multi-sample solids (MSS) probe capable of analyzing up to six samples simultaneously. In Phase I, an existing MSS design concept was developed by Revolution NMR and the University of Kansas for operation in the 200 - 400 MHz range, utilizing Revolution's experience and capabilities in probe design. In Phase II, this design will be enhanced so that the probe would be capable of performing most of the current suite of solids NMR experiments, including triple resonance capabilities. In addition, the MSS design will be modified for use at high frequencies (up to 900 MHz) as well as small and medium bore magnet sizes. Solid state nuclear magnetic resonance (NMR) is a very powerful tool for the analysis of new drugs and biomolecules, but its use is often limited by the fact that some experiments can require days or weeks. This project will provide a new tool which will allow up to six samples to be analyzed simultaneously. Pharmaceutical companies, government laboratories, and universities will be able to make more cost-effective use of their NMR systems in the development of new therapies