Deciphering Electron Transfer Pathways in Bacteria

酶催化的氧化反应是产生天然生物活性分子的关键因素。这些过程受到它们的电子转移伙伴的严格控制。该项目旨在从一种代谢多样的细菌中鉴定新的电子转移铁氧还蛋白。这些铁氧还蛋白在许多细菌中都很重要，它们的铁-硫簇结合基序中含有不同的非半胱氨酸氨基酸，而且定义很差。这些结果将促进对电子转移这一基本过程的理解。这将使与人类和植物病原体作斗争的战略成为可能，并释放这些系统作为生物催化剂的潜力，用于复杂和有价值的化学品的绿色化学合成。

Enzyme catalysed oxidation reactions are key players in the production of naturally occurring biologically active molecules. These processes are tightly regulated by their electron transfer partners. This project aims to characterise new electron transfer ferredoxin proteins from a metabolically diverse bacterium. These ferredoxins, important in many bacteria, contain different non-cysteine amino acids in their iron-sulfur cluster binding motifs and are poorly defined. The outcomes will advance understandings of electron transfer, a fundamental process. This will allow strategies to combat human and plant pathogens and unlock the potential of these systems as biocatalysts for the green chemical synthesis of complex and valuable chemicals.