In Vivo Imaging Neoplasia

描述（由申请人提供）： 该体内细胞和分子成像中心的建立 （ICMIC）将提供科学家之间的多学科互动 位于货车安德尔研究所和密歇根大学。ICMIC 将为这些互动提供一个框架， 在分子成像领域中的开发和新颖应用。这些 在P20（Pre-ICMIC）供资阶段发生的互动， 已经产生了一些最具创造性和洞察力的想法， 快速发展的研究领域称为分子成像。本申请 寻求建立在这些成功的科学互动和实验 结果，以提供在肿瘤学成像的重大进展。 这组调查人员努力工作， 使用高度新颖的分子成像构建体的整合方法， 成像方法来“报告”关键细胞和分子的发生 事件这些事件包括致癌作用（项目#2）、细胞凋亡（项目#3）、细胞凋亡（项目#4）和细胞凋亡（项目#5）。 #1）、癌基因的激活（项目#3）、血管生成（试点项目#1）和 转移（试点项目#2）。最初的生物学事件和 随后测量的生物反应可以使用 磁共振成像和光谱（MRI/S），体内生物发光 成像（BLI）和正电子发射断层扫描（PET）。这种多学科 和多模式方法将提供一个更完整的理解， 肿瘤转化过程中的整合事件 起始、进展、血管生成、转移、免疫应答，以及 总体治疗反应（或抗性）。这些研究不仅 提供了新的成像试剂和方法，用于检测这些生物 事件，但也将产生基因工程小鼠， 报告基因“内置”的非侵入性和动态成像这些 完整动物随时间发生的事件。如上所述，三项研究 项目和两个试点项目已经开发沿着职业生涯 发展计划和三个核心。职业发展计划提供 一个很好的机会，培训和互动的年轻和热情 分子成像领域的研究人员。行政核心A 提供行政支持，包括内部和外部科学 审查所有项目。小动物成像核心B提供 必要的专业知识和成像服务，包括microPET，MRI，microPET， 体内BLI、放射自显影、放射性药物合成和数字成像 处理.转基因动物核心C提供必要的专业知识， 集中资源，高效生产新颖而重要的 基因工程小鼠成像模型。这项研究计划是一项 在当前P20和R24 NCI支持下取得的进展的自然结果。 在密歇根州建立一个世界领先的ICMIC是一个优先事项， 密歇根大学和货车安德尔研究所做出的承诺 研究所沿着与密歇根州（资金分配通过生命 科学走廊），他们都与NIH一起做出了贡献， 为确保这一至关重要和 有趣的奋进

DESCRIPTION (provided by applicant): The establishment of this In Vivo Cellular and Molecular Imaging Center (ICMIC) will provide for multidisciplinary interactions between scientists located at the Van Andel Institute and the University of Michigan. The ICMIC will provide the framework for channeling these interactions into fully developed and novel applications in the field of molecular imaging. These interactions, which have occurred during the P20 (Pre-ICMIC) funding stage, have already yielded some of the most creative and insightful ideas in this rapidly evolving area of research termed molecular imaging. This application seeks to build upon these successful scientific interactions and experimental results in order to provide for significant advances in oncologic imaging. This group of investigators has worked diligently to bring together a uniquely integrated approach using highly novel molecular imaging constructs and imaging approaches to "report" occurrences of key cellular and molecular events. These events include carcinogenesis (Project #2), apoptosis (Project #1), activation of oncogenes (Project #3), angiogenesis (Pilot Project #1) and metastasis (Pilot Project #2). Both the initial biological event and the subsequent measured biological response can be noninvasively monitored using magnetic resonance imaging and spectroscopy (MRI/S), in vivo bioluminescence imaging (BLI) and positron emission tomography (PET). This multidisciplinary and multimodality approach will provide for a more complete understanding of the integrated events involved in the transformation process leading to tumor initiation, progression, angiogenesis, metastasis, immune response, and overall therapeutic response (or resistance). These studies will not only provide new imaging reagents and approaches for detection of these biological events, but will also yield genetically engineered mice which will have reporter genes "built-in" for noninvasively and dynamically imaging these events in intact animals over time. As mentioned above, three Research Projects and two Pilot Projects have been developed along with a Career Development Program and three Cores. The Career Development Program provides a great opportunity to train and interact with young and enthusiastic investigators in the field of molecular imaging. The Administrative Core A provides administrative support including Internal and External Scientific review for all projects. The Small Animal Imaging Core B provides the necessary expertise and imaging services including microPET, MRI, microPET in vivo BLI, autoradiography, radiopharmaceutical synthesis and digital image processing. The Transgenic Animal Core C provides the necessary expertise and centralized resources for efficient production of novel and important genetically engineered mouse imaging models. This research proposal is a natural outgrowth of the progress made with current P20 and R24 NCI support. Establishment of a world-leading ICMIC in Michigan is a priority and commitment made by the University of Michigan and the Van Andel Research Institute along with the State of Michigan (funds allocated through the Life Sciences Corridor) who have all contributed together with the NIH in order to provide the foundation necessary for ensuring the success of this vital and intriguing endeavor.