NICHD Cooperative Multicenter Neonatal Research Network

描述（由申请人提供）：NICHD新生儿研究网络是一个学术中心合作小组，执行多中心临床协议，研究新生儿医学问题，特别是与低出生体重、早产和常见新生儿医学问题有关的问题。印第安纳大学医学院是印第安纳州唯一的医学院和唯一的综合性儿童医院所在地，印第安纳州人口620万，每年出生85,000人。印第安纳大学医学中心和莱利儿童医院位于印第安纳波利斯州的地理中心，是高危围产期患者和危重新生儿的主要转诊中心。印第安纳新生儿研究网络中心包括8000多名婴儿和2000名新生儿重症监护病房住院患者的联合分娩服务（包括每年350名VLBW和200名ELBW婴儿）。自1991年以来，印第安纳州为新生儿研究网络做出了重大贡献，因为它有大量的患者，强大的师资力量，基础和临床研究经验，最先进的临床和研究设施，以及优秀的研究支持人员。在过去的五年中，印第安纳州为新生儿研究网络做出了重要的科学贡献，并一直将很大比例的受试者纳入通用数据库和网络进行的临床试验。詹姆斯·莱蒙斯博士作为网络首席调查员在过去的15年里发挥了巨大的领导作用。她是Brenda Poindexter博士的优秀导师，她一直积极参与网络活动的各个方面，并有资格在网络的下一个资助周期中担任首席研究员。印第安纳大学医学中心新生儿-围产期医学科的临床、教学和研究项目有着悠久的优秀传统。具体的专业领域包括临床试验、胎儿和新生儿营养、发育造血、分子免疫学和干细胞生物学。印第安纳大学强大的临床服务和广泛的研究经验是独特的平衡，并形成了这一竞争性更新申请的基础。

DESCRIPTION (provided by applicant): The NICHD Neonatal Research Network is a cooperative group of academic centers that perform multicenter clinical protocols to investigate problems in neonatal medicine, particularly those related to low birth weight, prematurity, and common neonatal medical problems. Indiana University School of Medicine is the only medical school and the site of the only comprehensive children's hospital in Indiana, a state with a population of 6.2 million and 85,000 annual births. Located at the geographical center of the state in Indianapolis, the Indiana University Medical Center and Riley Hospital for Children serve as the principal referral center for high-risk perinatal patients and critically ill neonates. The Indiana Neonatal Research Network Center includes a combined delivery service of more than 8000 infants and ~2000 NICU admissions (including 350 VLBW and 200 ELBW infants per year). Since 1991, Indiana has made substantial contributions to the Neonatal Research Network because of the large patient population, strong faculty, basic and clinical research experience, state-of-the-art clinical and research facilities, and excellent research support staff. In the past five years, Indiana has made important scientific contributions to the Neonatal Research Network and has consistently enrolled a large proportion of subjects to the Generic Data Base and to clinical trials conducted by the Network. Dr. James Lemons has provided tremendous leadership for the past 15 years as the Network Principal Investigator.and has served as an excellent mentor to Dr. Brenda Poindexter, who has been actively involved in all aspects of Network activities and is well qualified to assume to role of Principal Investigator during the next funding cycle of the Network. The clinical, teaching and research programs of the Section of Neonatal-Perinatal Medicine at Indiana University Medical Center have a long tradition of excellence. Specific areas of expertise include clinical trials, fetal and neonatal nutrition, developmental hematopoiesis, molecular immunology, and stem cell biology. The strong clinical service and extensive research experience at Indiana are uniquely balanced and form the basis for this competitive renewal application.