Chemical Toxicology in the Study of Disease Etiology

描述(由申请人提供) 本会议的拨款申请是为了资助一个题为“疾病病原学研究中的化学毒理学”的研讨会的部分资助。本次研讨会是美国化学学会化学毒理学分会将于2007年8月19日和22日在马萨诸塞州波士顿举行的第234届全国学会会议和博览会上提出的计划的一部分。本次研讨会的目的是向化学界介绍生物标记物和动物模型在确定疾病病因和药物发现方面的开发和应用方面的进展和挑战。由于环境毒素和药物的作用，用于量化和表征生物分子变化的工具在敏感性和特异性方面都有了显着的提高。这些工具的使用在人体暴露、病理生理学和疾病风险的生物标志物开发的体外和体内方面都是至关重要的。近年来，化学界对这一领域技术发展的贡献大大增加，未来的增长仅限于这一生物医学科学领域涉及的大量学科之间缺乏相互作用，因此需要召开这次研讨会。拟议专题讨论会的三届会议专门讨论这一领域感兴趣的关键领域，包括：a)斑马鱼作为化学毒理学的模型；b)基于DNA的生物标志物，以及c.)质谱学在化学毒理学中的应用。来自不同学科的备受尊敬的科学家已经同意公布他们在这些领域的最新发现。这次研讨会将与国家卫生研究院在环境健康、癌症病因学、老龄化和普通医学领域的目标特别相关。更广泛的科学界还将发现，所提供的信息与生物、药物和分析化学领域以及化学毒物学家有关。将向研究生和博士后研究员颁发旅行奖，以确保下一代科学家了解药物发现、质谱学、合成有机化学和化学致癌等领域的重要进展，以及他们如何共同努力开发确定疾病病因和风险的新方法。

DESCRIPTION (provided by applicant) This conference grant application requests funding for the partial support of a symposium with the title "Chemical Toxicology in the Study of Disease Etiology". This symposium is part of the program to be presented by the American Chemical Society Division of Chemical Toxicology at the 234th National Meeting and Exposition of the Society in Boston Massachusetts on August 19 and 22, 2007. The objective of this symposium is to bring to the chemical community, the advancements and challenges surrounding the development and application of biomarkers and animal models in the determination of disease etiology and drug discovery. Tools for the quantification and characterization of altered biological molecules that result from the action of environmental toxins and drugs have improved dramatically in both their sensitivity and specificity. The use of such tools is critical in the in vitro and in vivo facets of the development of biomarkers of exposure, pathophysiology and disease risk in humans. The contribution of the chemical community to the development of techniques in this arena has increased greatly in recent years, with future growth only limited by lack of cross-talk between the large numbers of disciplines involved in this area of the biomedical sciences, hence the need for this symposium. The three sessions of the proposed symposium are devoted to critical areas of interest in this arena and include: a.) Zebrafish as a model for chemical toxicology; b) DNA-based biomarkers, and c.) Applications of mass spectrometry in chemical toxicology. Highly respected scientists from a variety of disciplines have agreed to present their most recent findings in these areas. The symposium will have particular relevance to the goals of the National Institutes of Health in the areas of environmental health, cancer etiology, aging and general medicine. The broader scientific community will also find the information presented relevant in the fields of biological, medicinal and analytical chemistry as well as chemical toxicologist. Travel awards will be made to graduate students and postdoctoral fellows to ensure that the next generation of scientists is aware of the important advances in the fields of drug discovery, mass spectrometry, synthetic organic chemistry and chemical carcinogenesis to mention a few and how they work in concert to develop new ways to determine disease etiology and risk.