2007 Cell Biology of Metals Gordon Research Conference

描述(由申请人提供)：2006年金属细胞生物学戈登会议的主要目标是提供一个论坛，介绍这一新兴领域的新发展和交流想法。这次会议将汇集从资深研究人员到研究生的科学家，介绍和讨论涉及铜、铁和锌离子以及相应的金属蛋白的真核细胞生物学的最新进展。金属的细胞生物学包括金属在细胞和细胞器中的摄取、分布和使用。金属被跨膜吸收，并被引导到不同的细胞目的地，最终进入正确的金属蛋白。复杂的机制控制着蛋白质的摄取、分配、运输和插入。涉及转运蛋白、螯合剂、金属辅因子、伴侣(经典意义)、金属分配伴侣、转录因子和翻译调节因子。其复杂程度等同于现代细胞生物学中所描述的蛋白质运输途径。一个重要的目标是了解蛋白质运输途径和金属运输途径是如何整合和相交的。其他目标是了解细胞如何实现金属离子动态平衡，细胞如何感知不同的金属离子，以及不同金属离子的动态平衡机制如何相互联系。如果金属稳态的任何步骤被扰乱，细胞故障或疾病就会接踵而至，而会议将带来这些疾病联系。 会议一般将根据细胞结构、跨金属(铁、铜、锌、钼)和进化类别来组织。会议计划讨论金属进入细胞的运输、内吞和分泌室中的金属、线粒体和铁、线粒体和铜、叶绿体中的金属、金属辅因子、全球监管计划中的金属以及金属分配和传感。金属细胞生物学会议的新颖性在于它对与金属离子有关的细胞生物学问题的独特关注，以及对多种生理离子的关注。

DESCRIPTION (provided by applicant): The principal objective of the 2006 Cell Biology of Metals Gordon Conference is to provide a forum for presentation of new developments and for exchanging ideas in this emerging field. The meeting will bring together scientists, ranging from established investigators to graduate students, to present and discuss the most recent advances in eukaryotic cell biology involving copper, iron and zinc ions and the corresponding metalloproteins. The cell biology of metals encompasses the uptake, distribution and use of metals in cells and organelles. Metals are taken up across membranes and are directed to various cellular destinations, ultimately finding their way into the correct metalloproteins. Intricate mechanisms control uptake, distribution, trafficking, and insertion into proteins. Transporters, chelators, metal cofactors, chaperones (classic sense), metallochaperones, transcription factors and translation regulators are involved. The level of complexity equals that of the protein trafficking pathways that have been characterized in modern cell biology. An important goal is to understand how protein trafficking pathways and metal trafficking pathways are integrated and intersect. Other goals are to understand how cells achieve metal ion homeostasis, how cells sense diverse metal ions, and how homeostatic mechanisms for different metal ions are interconnected. Cellular malfunction or disease ensue if any of the steps in metal homeostasis are perturbed, and the meeting will bring out these disease links. The sessions will generally be organized according to cell structure, cutting across metals (Fe, Cu, Zn, Mo) and evolutionary categories. Sessions are planned to address transport of metals into cells, metals in endocytic and secretory compartments, mitochondria and iron, mitochondria and copper, metals in chloroplasts, metal cofactors, metals in global regulatory programs and metal allocation and sensing. The novelty of the Cell Biology of Metals Conference lies in its unique focus on cell biological issues related to metal ions and the focus on multiple physiological ions.