8th International Primary Hyperoxaluria Workshop

描述(申请人提供)：这是一份申请资金，以部分支持于2007年6月29-30日在英国伦敦举行的第八届国际原发性高草酸尿症研讨会。这次研讨会是自1990年以来每2-3年举办一次的系列研讨会中的第8次，上一次研讨会于2004年在明尼苏达州罗切斯特举行。2007年的会议将是该研讨会首次在伦敦举行，尽管这座城市在20世纪80年代、90年代和21世纪初曾是PH值研究进展的中心。虽然最初这些研讨会的性质完全是欧洲的，但它们现在已经演变成真正的国际性。预计与会者将来自世界各地，包括欧洲、北美、澳大拉西亚和亚洲。这些研讨会是目前为临床医生、临床科学家和基础科学家提供的唯一机会，他们可以聚在一起讨论遗传性高草尿症和草酸病的最新实验室发现，以及如何将这些发现迅速转化为临床管理的改进。在过去的15年里，我们对原发性高草酸尿症的分子病因学和病理生理学的理解取得了巨大的进步，部分原因是在这些研讨会上进行了激动人心的讨论和互动。其中包括专门为患者、家人和朋友设计的课程，这些人都在某种程度上受到PH的影响，他们有机会与研究这种疾病的科学家打成一片。目前，在25位科学/临床特邀演讲者中，有9位来自美国，然而，预计将有更多的美国科学家，特别是年轻的研究人员参加讨论，并在简短的口头陈述或海报会议上介绍他们的工作。这一系列的两年一次/三年一次的PH研讨会是目前来自许多不同学科的专家(例如，儿童和成人肾脏病、移植外科、代谢医学、分子和细胞生物学、临床和分子遗传学)的唯一机会，讨论他们对原发性高草酸尿的共同兴趣。

DESCRIPTION (provided by applicant): This is an application requesting funds to partially support the 8th International Primary Hyperoxaluria Workshop being held in London, United Kingdom, on June 29 - 30, 2007. This Workshop is the 8th in a series that has run every 2-3 years since 1990 and the previous workshop was held in Rochester, MN in 2004. The meeting in 2007 will be the first time the workshop has been held in London, even though this city was at the center of the advances in PH research in the 1980s, 1990s, and early 2000s. Although at the beginning these workshops were decidedly European in nature, they have now evolved to become truly international in character. Participants are expected from all corners of the globe, including Europe, North America, Australasia and Asia. These workshops are the only opportunity currently available for clinicians, clinical scientists and basic scientists to get together to discuss the latest laboratory findings in the hereditary hyperoxalurias and oxaloses and how they might be speedily translated into improvements in clinical management. The tremendous advances in our understanding of the molecular etiology and pathophysiology of the primary hyperoxalurias over the past 15 years have been in part due to the stimulating discussions and interactions that have taken place at these workshops. A session specifically designed for patients, families and friends is included and opportunities for these individuals, who are all affected by PH in one way or another, to intermingle with the scientists who research this disease are built into the program. Presently, of the 25 scientific/clinical invited speakers, 9 are from the United States, however, it is expected that many more American scientists, especially young investigators, will participate in the discussions and present their work in short oral presentations or in the poster sessions. This series of bi/triennial PH workshops is the only opportunity currently available for specialists from many different disciplines (e.g. pediatric and adult nephrology, transplant surgery, metabolic medicine, molecular and cell biology, clinical and molecular genetics) to discuss their common interest in Primary Hyperoxaluria.