Aspen Perinatal Biology Symposium

描述（由申请人提供）：本申请寻求差旅费资金，以使来自美国的12名受训人员或新研究者能够出席2007年白杨围产期生物学研讨会，并寻求资金支持两名美国高级研究者参加此次会议的差旅费和每日津贴费用，他们将在会议上应邀发表全体演讲并参加研讨会。美国围产期研究的悠久传统巩固了我们对胎儿发育生理基础的认识。在过去10年中，细胞和分子技术被纳入研究，使人们能够深入了解胎儿生理学的发育基础和先兆子痫、IUGR、糖尿病和早产的病理生理学，以及与围产期发病率和死亡率相关的情况。人们越来越认识到，子宫内的生命与成年期疾病的发展有关，即健康和成人疾病或胎儿编程的发育起源。这重新引起了人们对围产期生理学的兴趣。围产期研究社区是多学科的;汇集了对母体，胎儿和胎盘生理学感兴趣的临床医生和基础科学家以及大量从事与人类生理学和发育密切相关的比较研究的农业动物生理学家。它也有培养年轻的基础和临床科学家的悠久传统;他们的培训经验的一个重要组成部分是在他们可以与资深科学家互动的场所展示工作的机会，并从榜样那里获得指导的好处。北美围产期研究界特别是已由FASEB主办的一系列会议。FASEB赞助的一个条件是严格要求只邀请高级调查员作为特邀演讲者，并安排年轻调查员和受训人员参加海报会议，但不允许他们口头介绍或与高级调查员互动的最大机会。在最后一次围产期生物学会议上，决定组织一次独立会议，其形式允许年轻研究者进行口头陈述，并有机会与高级研究者进行更多的互动。本次会议将围绕“健康后代的发育和异常发育的长期后果”这一综合主题，介绍来自孕产妇、胎儿、胎盘和农业动物研究界的情况。“会议将为期两天半，八次口头全体会议，每次会议包括新的研究人员，每个系统两次，涉及健康后代和发育。在全体会议的同时，还举行了一次互动研讨会，讨论有争议的问题。安排了两次3小时的海报讨论会，并将在整个会议期间展示海报，以便有时间深入讨论工作。学员或新研究员的最佳海报展示将获奖。将根据科学委员会对提交的第一作者摘要的审查选择受训人员和新研究者，以获得差旅费。美国的高级研究者将由会议组织者和本提案的PI选择。在围产期研究会议上，妇女出席者、发言者和会议主席的比例总是很高（高达40%），以确保充分的代表性。本次会议补助金申请的目的是为12名实习生/年轻的研究人员提供旅费，以帮助支持他们参加2007年白杨围产期生物学研讨会。它还将为两名美国高级科学家提供支持，以出席会议，发表全体报告并参加研讨会。会议的主题是“健康后代的发育和异常发育的长期后果”。“这对公共卫生产生了重大影响，人们越来越认识到子宫内的生命是成年人疾病的主要决定因素。会议将以综合的方式汇集孕产妇，胎儿和胎盘生理学家与农业科学家一起使用与围产期生物学相关的动物模型。

DESCRIPTION (provided by applicant): This application seeks funding for travel costs to allow the attendance of 12 trainees or new investigators from the USA at the Aspen Perinatal Biology Symposium 2007 together with funding to support the travel and per diem costs of two senior US-based investigators to this meeting where they each will present an invited plenary lecture and take part in workshop sessions. The longstanding tradition of perinatal research in the US underpins our knowledge of the physiologic basis of fetal development. Cellular and molecular techniques incorporated into investigation in the last 10 years has allowed in depth understanding of the developmental basis of fetal physiology and the pathophysiology of preeclampsia, IUGR, diabetes and premature delivery, situations associated with perinatal morbidity and mortality. There has been a burgeoning recognition that life in utero is associated with the development of disease in adult life i.e. the developmental origins of health and adult disease or fetal programming. This has brought renewed interest in perinatal physiology. The perinatal research community is multidisciplinary; bringing together clinicians and basic scientists interested in maternal, fetal, and placental physiology and a substantial cadre of agricultural animal physiologists who perform comparative studies of great relevance to human physiology and development. It also has a strong tradition of training young basic and clinician scientists; a vital part of their training experience is the opportunity to present work in venues where they can interact with senior scientists, and receive the benefit of mentorship from role models. The North American perinatal research community specifically has been served by a series of meetings sponsored by FASEB. A condition of FASEB sponsorship is a strict requirement for inclusion of only senior investigators as invited speakers and a schedule including young investigators and trainees in poster sessions but not allowing them oral presentations or maximal opportunities to interact with senior investigators. At the last perinatal biology meeting it was decided to organize a stand alone meeting with a format allowing oral presentations by young investigators and opportunities for more interaction with senior investigators. This meeting will feature presentations from maternal, fetal, placental and agricultural animal research communities together around an integrated theme of "The development of healthy offspring and the long term consequences of abnormal development." The meeting will be 2 1/2 days with eight oral plenary sessions each including new investigators, two for each system related to healthy offspring and development. Plenary sessions are accompanied by an interactive workshop session addressing controversial questions. Two 3-hour poster discussion sessions are scheduled and posters will be displayed for the entire meeting to allow time for in-depth discussion of work. Prizes will be awarded for the best poster presentations by trainees or new investigators. Trainees and new investigators will be selected based on review of submitted first author abstracts by the scientific committee for award of travel funds. The US-based senior investigators will be selected by the meeting organizers and PI of this proposal. There always is a high proportion (up to 40%) of women attendees, speakers and session chairs at perinatal research meetings ensuring adequate representation. Purpose The purpose of this conference grant application is to provide travel funds for 12 trainee/young investigators to help support their attendance at the 2007 Aspen Perinatal Biology Symposium. It will also provide support for two senior US- Based scientists to attend the meeting give a plenary presentation and participate in workshop sessions. The theme of the conference is "The development of healthy offspring and the long term consequences of abnormal development." This has major public health consequences with the growing recognition that life in utero is a major determinant of disease in adult life. The conference will bring together in an integrated manner maternal, fetal and placental physiologists together with agricultural scientists using animal models of relevance to perinatal biology.