The Fourth International Leukocyte Signal Transduction Workshop: Clinical Implica

适当的免疫反应依赖于不同的白细胞和其他细胞之间的复杂相互作用。 类型及其可溶性产物，以及在许多受体之间的强烈串扰，这些受体转导 激活信号导致细胞特异性基因程序的诱导、分化、增殖和 获取效应器功能。免疫反应失调可能会导致有害的结果， 自身免疫性疾病的发展就是一个最好的例子。异常的机制导致 炎症和自身免疫的发展在很大程度上是由遗传学解释的 对老鼠的操纵，这导致了对潜在信号机制的重大洞察。因此， 特定步骤的信号通路的基因改变可以预防或诱导糖尿病的发生 自身免疫性和其他免疫性疾病。尽管如此，小型科学会议允许 密集的互动和富有成效的讨论，同时将致力于 白细胞信号通路的基本情况及其临床意义 (包括相关的疾病模型)相去甚远。 请求提供资金以支持题为？第四次国际白细胞信号的国际会议 信号转导研讨会：信号通路的临床意义？将在希腊罗兹举行， 6/3-8/07年。这是自2000年以来举行的一系列类似会议中的第四次。上一首 会议完全集中在白细胞受体信号转导的基本方面。这个 即将举行的会议预计将有大约120人参加，这将是对这一重点的重大偏离。 组委会这次起草了一项计划，将致力于 白细胞信号的基本方面以及相关动物疾病模型和临床的研究 这些信号通路的含义。此外，几个受邀的讲座将介绍和讨论相关的 尖端技术。受邀教职人员由23名国际知名科学家组成(除 组织委员会)，他们是相关研究领域的公认专家。早期的科学家们， 他们在职业生涯的形成阶段将优先参与和展示。团结在一起， 参加这个研讨会的科学家涉及不同的研究领域，其中包括 全面的范围，从亚细胞、生化水平的分析，到整个细胞和动物 模型，以及最多的临床应用。 讲习班的具体目标是： 1.扩展并继续之前的三个高生产率的白细胞信号转导研讨会。 2.汇聚国际知名科学家，他们是白细胞信号转导和 白细胞信号通路对疾病的影响，如炎症、自身免疫和 传染病，以介绍和讨论最新的相关研究。 3.在科学家职业生涯形成的早期阶段，即初级教员(助理) 教授)、博士后研究员和研究生有机会介绍和讨论 他们自己正在进行的工作，并从与领先科学家的密切、一对一的互动中受益，从而 提供教育经历并激励自己致力于临床相关的 科研事业。 主办方预计，本次研讨会将促进思想交流、密切互动和 致力于白细胞信号基本方面的科学家和研究人员之间的合作 动物模型(甚至人类)炎症性和自身免疫性疾病。

A proper immune response depends on complex interactions between different leukocytes and other cell types and their soluble products, and on an intensive crosstalk among many receptors, which transduce activation signals leading to induction of cell-specific gene programs, differentiation, proliferation, and acquisition of effector functions. A dysregulated immune response can lead to harmful results, the development of autoimmune diseases being a prime example. Aberrant mechanisms that lead to development of inflammation and autoimmunity have been elucidated to a large degree by the genetic manipulation of mice, which led to significant insights into the underlying signaling mechanisms. Thus, genetic alteration of signaling pathways at defined steps can prevent or induce the development of autoimmunity and other immunological diseases. Nevertheless, small scientific meetings that allow intensive interactions and fruitful discussions and, at the same time, bring together scientists working on fundamental aspects of leukocyte signaling pathways and on the clinical implications of these pathways (including relevant disease models) are far and few between. Funds are requested to support an international conference entitled ?The 4th International Leukocyte Signal Transduction Workshop: Clinical Implications of Signaling Pathways? to be held in Rhodes, Greece, between 6/3-8/07. This is the 4th in a series of similar meetings, which were held since 2000. Previous meetings focused exclusively on basic aspects of signal transduction by leukocyte receptors. The upcoming meeting, with ~120 anticipated participants, will represent a significant departure from this focus. The Organizing Committee has drafted this time a program, which brings together scientists working on fundamental aspects of leukocyte signaling and those studying relevant animal disease models and clinical implications of these signaling pathways. In addition, several invited talks will present and discuss relevant cutting edge technologies. The invited faculty consists of 23 internationally known scientists (in addition to the Organizing Committee) who are recognized experts in relevant research areas. Scientists at the early, formative stage of their career will be given priority in participation and presentation. Together, the scientists participating in this Workshop cover different areas of research, which encompass a comprehensive range, from the subcellular, biochemical level of analysis, through whole cell and animal models, and up to clinical applications. The Specific Aims of the Workshop are: 1. Extend and continue three previous, highly productive Leukocyte Signal Transduction Workshops. 2. Bring together internationally known scientists, who are experts in leukocyte signal transduction and the disease implications of leukocyte signaling pathways to, e.g., inflammation, autoimmunity, and infectious disease, in order to present and discuss the most up-to-date relevant research. 3. Give scientists at an early stage of their formative career, i.e., junior faculty members (assistant professors), postdoctoral research fellows and graduate students an opportunity to present and discuss their own ongoing work and to benefit from close, one-on-one interactions with leading scientists, thereby providing an educational experience and a motivation to commit themselves to a clinically relevant scientific research career. The Organizers anticipate that this Workshop will promote sharing of ideas, close interactions and collaborations between scientists working on basic aspects of leukocyte signaling and those studying animal model (or even human) inflammatory and autoimmune diseases.