New Frontiers in Pediatric Traumatic Brain Injury

描述（由申请人提供）：过去几十年的研究在我们对儿童创伤性脑损伤（TBI）结果的理解和管理方面取得了许多进展，但之前的研究往往发生在独立的学术领域，相对而言，跨领域或学科的整合很少。在多个领域（例如，神经恢复的基因组学和蛋白质组学）中发生的科学进步不太可能在TBI儿童的临床管理中取得重大进展，直到它们成为跨多个分析层次的合作研究的主题。因此，召开跨学科会议以促进综合和转化研究的时机似乎已经成熟。最近没有会议关注“最先进”的儿科脑外伤研究和促进研究人员之间的网络和合作。因此，pi建议召开一次儿科TBI前沿研究会议。会议议程将旨在促进多层次、综合性和转化性的研究，并鼓励新老研究者开展与这一目标一致的研究。会议计划将强调需要在一系列层面（即生物、医学、心理、社会）调查导致儿童脑外伤后结果变化的因素，并将研究结果转化为有效的治疗和干预措施。会议将包括来自多个学科的个人演讲者的演讲，小组讨论和海报专题讨论会。该计划将涉及一系列主题：基因组学/蛋白质组学；神经病理学和病理生理学；神经影像;医疗干预和临床试验；神经行为的结果;社会心理干预和康复。会议应该吸引多学科的听众，包括现有的和新的研究者，以及研究生和博士后研究员。这次会议的目的与其说是对过去研究的全面回顾，不如说是一个展示新方法的论坛，这些方法说明了多层次、综合和转化的研究，并促进了未来的研究。创伤性脑损伤（TBI）是15岁以下青年死亡和残疾的主要原因，因此是一个重大的公共卫生问题。据估计，每年有超过17000名儿童因创伤性脑损伤而终身残疾。一个前沿的研究会议将促进对儿童创伤性脑损伤结果的更好理解，并有助于为创伤性脑损伤儿童提供更有效的治疗和干预。

DESCRIPTION (provided by applicant): Research over the past few decades has resulted in many advances in our understanding and management of the outcomes of pediatric traumatic brain injury (TBI), but prior research has often occurred in separate academic silos, with relatively little integration across domains or disciplines. The scientific advances that have occurred within domains (e.g., genomics and proteomics of neural recovery) are not likely to result in significant progress in the clinical management of children with TBI until they become the topic of collaborative research that cuts across multiple levels of analysis. Thus, the time appears to be ripe for an interdisciplinary conference that promotes integrative and translational research efforts. No recent conference has focused on the 'state-of-the-art' of research on pediatric TBI and promoting networking and collaboration among investigators. The PIs therefore propose a cutting-edge research conference on pediatric TBI. The conference agenda will be designed to promote multi-level, integrative, and translational research, and to encourage both new and established investigators to undertake research consistent with this goal. The conference program will highlight the need to investigate factors across a range of levels (i.e., biological, medical, psychological, social) that account for variations in outcomes following pediatric TBI and to translate the results of research into effective treatments and interventions. The conference will include presentations by individual speakers from multiple disciplines, panel discussions, and poster symposia sessions. The program will address a range of topics: genomics/proteomics; neuropathology and pathophysiology; neuroimaging; medical intervention and clinical trials; neurobehavioral outcomes; psychosocial intervention and rehabilitation. The conference should attract a multidisciplinary audience that includes both established and new investigators, as well as graduate students and postdoctoral fellows. The conference will be designed not so much as a comprehensive review of past research as a forum for presentation of newer approaches that illustrate multi-level, integrative, and translational research and promote such research in the future. Traumatic brain injury (TBI) is a leading cause of death and disability in youth under the age of 15, and therefore represents a major public health problem. Estimates suggest that over 17,000 children are left with permanent disabilities as a result of TBI each year. A cutting-edge research conference will promote a better understanding of the outcomes of childhood TBI and help engender more effective treatment and intervention on behalf of children with TBI.