Matrix Metalloproteinases Gordon Conference

Gordon Research Conferences汇集了选定科学领域的活跃研究人员，旨在通过正式演讲和广泛讨论来定义和分析重要问题，最新进展和研究机会。 该提案的具体目的是为2005年戈登基质金属蛋白酶研究会议以及2007年和2009年的会议获得部分资金。 2005年会议是MMP戈登研究会议的第七次两年期会议，将在蒙大拿州大天空度假村举行。 MMPs及其亲属在正常发育和生理学中以及在与组织破坏相关的许多病理学状况中发挥核心作用，所述病理学状况包括癌症、关节炎、牙周炎、溃疡、动脉粥样硬化、肺纤维化、退行性眼病、感染和炎症。 会议将继续为讨论结构，功能，靶标，抑制剂和分子机制的最新进展提供论坛。 其目标是创造一种氛围，在具有共同兴趣的调查人员之间编织线索，并使那些采用更多样化方法的人相互受益。 2005年会议将包括八个科学会议：1.金属蛋白酶：酶和底物的结构生物学;降解，可视化MMPs; 2。干细胞、发育和衰老中的金属蛋白酶; 3.炎症中的金属蛋白酶; 4.金属蛋白酶在神经系统-神经退行性疾病，记忆和衰老; 5。ADAM和ADAMTS家庭在发展和疾病; 6。癌症中的金属蛋白酶; 6.金属蛋白酶抑制剂-TEVIP及其他; 8，金属蛋白酶基因调控，细胞生物学，活化和受体; 9. MMPs-下一代 会议计划举办两次海报会议，以鼓励学生、博士后研究员和年轻的研究人员加入高级研究人员的行列，介绍他们的工作。 将鼓励所有与会者提交海报会议的摘要，使所有与会者有机会展示数据并充分参与讨论。 传统上，这次会议汇集了不同的国际学术和工业科学家团体，他们的兴趣范围从基本的分子，细胞和生理机制MMP作用，到对MMP作为治疗靶点感兴趣的医生科学家。 有限的出席人数、重点突出的科学会议和非常成功的海报会议联合收割机结合起来，为交流思想提供了一个令人兴奋的论坛，并为对MMPs、相关酶及其抑制剂感兴趣的多元化科学家群体提供了广泛的参与机会。 因此，我们正在申请资金，以部分支持关于MMP的GRC，以确保在这个关键和具有高度影响力的会议上展示最相关和最新的信息。

DESCRIPTION (provided by applicant): Gordon Research Conferences bring together active researchers in a selected scientific field with the purpose of defining and analyzing important problems, recent advances and opportunities for research through both formal presentations and extensive discussion. The specific aim of this proposal is to obtain partial funding for the 2005 Gordon Research Conference on Matrix Metalloproteinases (MMPs) and for the conferences in 2007 and 2009. The 2005 Conference represents the 7th biennial meeting of the MMP Gordon Research Conference, and will be held at Big Sky Resort, Big Sky, Montana. MMPs and their relatives play a central role in normal development and physiology and in many pathological conditions associated with tissue destruction, including cancer, arthritis, periodontitis, ulcerations, atherosclerosis, lung fibrosis, degenerative eye diseases, infection and inflammation. The conference will continue to provide a forum for discussion of the latest advances in structure, function, targets, inhibitors and molecular mechanisms. The goal is to create an atmosphere that will weave threads among investigators with common interests, and cross-fertilize those with more diverse approaches. The .2005 conference will consist of eight Scientific Sessions: 1. The Metalloproteinase Toolbox: Structural Biology of Enzymes and Substrates; The Degradome, Visualizing MMPs; 2. Metalloproteinases in Stem Cells, Development and Ageing; 3. Metalloproteinases In Inflammation; 4. Metalloproteinases in The Nervous System-Neurodegenerative Diseases, Memory and Aging; 5. ADAM and ADAMTS Families In Development And Disease; 6. Metalloproteinases in Cancer; 6. Inhibitors Of Metalloproteinases-TEVIPs And Others; 8, Metalloproteinase Gene Regulation, Cell Biology, Activation And Receptors; 9. MMPs-The Next Generation. Two Poster Sessions are planned for the conference to encourage students, postdoctoral fellows and young investigators to join senior investigators in presenting their work. All meeting participants will be encouraged to submit an abstract for the Poster Sessions, allowing all attendees the opportunity to present data and fully participate in discussions. Traditionally, this conference brings together a diverse international group of academic and industrial scientists with interests ranging from basic molecular, cellular and physiological mechanisms MMP action, to physician-scientists interested in MMPs as therapeutic targets. The limited attendance, focused Scientific Sessions, and highly successful Poster Sessions combine to provide an exciting forum for the exchange of ideas and to provide extensive opportunities for participation by a diverse group of scientists interested in MMPs, related enzymes and their inhibitors. Therefore, we are requesting funds to partially support the GRC on MMPs to assure that the most relevant and up-to-date information is featured at this pivotal and highly influential meeting.