Translation of a rapid integrated tendon repair system

手部肌腱损伤的发生率为每年每10万人中有28人。屈肌腱损伤约占手部肌腱损伤的40%，许多患者存在多发肌腱损伤。屈肌腱损伤主要影响劳动年龄的年轻男性涉及体力劳动。手部肌腱损伤会严重致残，需要12周的康复时间。平均而言，单次屈肌腱修复费用为1330英镑，由于缺勤而产生的相关康复和社会成本估计约为1.5万英镑。其中一些肌腱由于肌肉收缩，修复起来非常困难，这导致断裂的肌腱末端进一步缩回到宿主组织中。目前，在不破坏周围结构的情况下恢复断裂的近端肌腱是非常困难的，这往往导致粘连形成，从而限制了功能预后。肌腱损伤主要通过缝合修复；肌腱修复技术的进展也很有限。研究表明，缝线修复会导致肌腱组织的高应力区，从而导致细胞死亡和瘢痕形成。屈肌腱修复仍未得到满足，只有75%的修复达到满意的功能效果，再手术率为11%。

The incidence rate of hand tendon injuries is 28 per 100,000 per annum. Flexor tendon injuries account for ~40% hand tendon injuries and many patients suffer from multiple tendon injuries. Flexor tendon injuries predominantly affect working-aged young males involving manual labour. Hand tendon injuries can be severely disabling, which requires a rehabilitation time of 12 weeks. On average, a single flexor tendon repair costs £1330, and its associated rehabilitation and societal costs due to absence from work are estimated to be around £15,000. Some of these tendons in particular are very challenging to repair due to muscle contraction, which leads to the severed tendon end retracting further into the host tissue. At present, retrieving the severed proximal tendon is very difficult without damaging the surrounding structures, which often leads to adhesion formation and thus limited functional outcome. Tendon injuries are predominantly repaired with sutures; and there has been limited progress in tendon repair techniques. It has been shown that suture repairs lead to high stress areas on tendon tissue which cause cell death and scar formation. Flexor tendon repair remains an unmet need as only 75% repairs achieve a satisfactory functional result with an 11% reoperation rate.