Epilepsy Research Training Program

描述(由申请人提供)：癫痫研究培训计划将为博士后学员提供密集的概念和技术研究培训，培训主题和尖端技术与癫痫的理解密切相关。这些领域包括神经元和网络的超兴奋性、可塑性和修复的神经生物学，以及参与癫痫状态产生和维持的遗传/基因组、细胞和分子机制。该计划是为最近完成医学博士或博士培训的个人设计的，将使他们参与基础和转化性研究方法，以满足NIH战略计划中强调的治疗癫痫的研究需求。该计划的目标是培养下一代癫痫研究人员，他们不仅将利用现有的方法和概念，而且将准备将其发扬光大。研究培训将由学徒提供，由一名或多名教员直接赞助，并由一个单独的培训委员会指导和监督。除了这种研究培训外，还将积极参加该计划的结构化培训研讨会，以及期刊俱乐部、临床/研究研讨会和专门培训课程，包括研究的伦理行为。该项目位于UCI研究园区，包括几个神经科学系和多学科研究中心的人类基因组、生物医学工程和计算建模、神经元死亡和再生以及老龄化和痴呆症的教师。因此，该项目的背景是一个既有基础神经科学，也有包括癫痫在内的临床疾病研究方法的社区。该计划的指导人员包括在关键方面和方法方面拥有专业知识的基础科学家，这些方面和方法对癫痫的研究至关重要，以及提供关键临床观点的内科科学家。因此，该计划将提供有针对性的多维研究培训，以培养癫痫的神经生物学、遗传学、细胞和分子机制方面的下一批研究人员。

DESCRIPTION (provided by applicant): The Epilepsy Research Training Program will provide intensive conceptual and technical research training to postdoctoral trainees, in research topics and cutting-edge techniques germane to the understanding of the Epilepsies. These areas include the neurobiology of neuronal and network hyperexcitability, plasticity and repair, and the Genetic/Genomic, Cellular and Molecular mechanisms involved in the generation and maintenance of the epileptic state. The program is designed for individuals who have recently completed their MD or PhD training, and will engage them in basic and translational research approaches, to fulfill the need for research to Cure Epilepsy, as highlighted in the NIH strategic plan. The Program's goal is to create the next generation of Epilepsy Researchers, who will not only utilize methods and concepts currently in place, but will be prepared to carry them forward. The Research training will be provided by an apprenticeship under the immediate sponsorship of one or more faculty preceptor, with guidance and oversight of an Individual Training Committee. This research training will be complemented by active participation in the program's structured training seminars, as well as in journal clubs, clinical/research symposia and specialized training courses, including the ethical conduct of research. The program is located at the UCI Research Campus, and includes faculty in several Neuroscience departments and in the multi-disciplinary Research Centers for Human Genome, Biomedical Engineering and Computational Modeling, Neuronal Death and Regeneration and Aging and Dementia. Thus, the program's setting is a community rich in both, Basic Neuroscience as well as in research approaches to Clinical Disorders, including Epilepsy. The preceptors of this program include basic scientists with expertise in key aspects and methods, which are crucial to the study of Epilepsy, as well as physician-scientists who offer a critical clinical perspective. The program will thus provide focused yet multi-dimensional research training to generate the next cadre of researchers in the Neurobiology, Genetics, Cellular and Molecular mechanisms of the Epilepsies.