Fragmented early-life experiences, aberrant circuit maturation, emotional vulnerabilities

项目总结 自杀想法和行为(STB)是导致幼儿死亡的第五大主要原因，也是非致命的 在这个年龄段，性传播疾病占急诊室就诊人数的近一半。目前还缺乏研究检验 青春期前儿童中的性传播疾病以及迫切需要有效的筛查工具来识别有需要的儿童 干预的结果。现有的STB研究倾向于进一步排除边缘背景的个人 限制了本已稀少的研究在这一人群中的推广能力。改善儿童的自杀预防 需要对这一弱势群体进行研究创新。有三个特别关键的障碍来确定 患有性病的儿童：1)父母担心性病的评估是医源性的；2)缺乏发育 识别儿童风险的适当工具和方法；以及3)缺乏文化上适当和有效的工具来 解决家长关注的问题并确定儿童风险。本增刊直接回应NOT-MH-22-195 通过利用现有的社会文化队列，解决在幼儿中识别性传播疾病的这些障碍 而经济上不同的母亲和她们5到8岁的孩子，从出生前就紧随其后 由NIMH孔德中心赠款支持的认知和情绪发展综合评估 (P50 MH096889)。这一副刊吸收了批判性的社区观点，测试了以下目标：1. 提供在5至8年内评估和量化STB的发展和文化上合适的方法-- 大孩子；2.测试短暂的信息干预的有效性，以增加父母对探查STB的同意 在5至8岁儿童中；3.验证/实施新的STB评估工具，利用 具有彻底的特征和文化多样性的队列。该项目产生的发现解决了关键问题 在开发工具以准确评估需要救生干预的幼儿中的性传播疾病方面存在差距。 此外，拟议的补助金属于父母津贴的范围，并丰富了这一范围。家长助学金 调查快感缺乏的早期起源，由于性传播疾病通常伴随或跟随快感缺乏，本补充资料 提供了一个重要的补充性成果衡量标准。此外，家长拨款还探讨了 精神病理学中不可预测的早期生活经历和补充材料的目标3使评估 不可预测性在STB中的作用。本研究有可能改变儿童性传播疾病的研究， 通过提高家长对评估STB的同意，以及增加对STB有效性的信心 对儿童的评估。

PROJECT SUMMARY Suicidal thoughts and behaviors (STBs) are the 5th leading cause of death among young children and non-fatal STBs account to close to half of emergency room visits in this age group. There is a dearth of research examining STBs among pre-adolescent children and a critical need for validated screening tools to identify children in need of intervention. Existing STB research tends to exclude individuals from marginalized backgrounds further limiting the generalizability of already sparse research in this population. Improving suicide prevention in children requires research innovation for this vulnerable group. There are three particularly critical barriers to identifying children at risk of STBs: 1) parental fears that STB assessment is iatrogenic; 2) lack of developmentally appropriate tools and methods for identifying child risk; and 3) lack of culturally appropriate and valid tools to address parent concerns and to identify child risk. This supplement in response to NOT-MH-22-195 directly addresses these barriers to identifying STBs in young children by leveraging an existing cohort of socioculturally and economically diverse mothers and their 5- to 8-year-old children, followed intensively from before birth with comprehensive assessments of cognitive and emotional development supported by a NIMH Conte Center grant (P50 MH096889). Incorporating critical community perspectives, this supplement tests the following aims: 1. Provide developmentally and culturally appropriate methods for assessing and quantifying STBs in 5- to 8-year- old children; 2. Test the efficacy of a brief informational intervention to increase parent consent to probe STBs in 5- to 8-year-old children; 3. Validate/implement novel instruments for STB assessment capitalizing on a thoroughly characterized and culturally diverse cohort. The discoveries generated by this project address critical gaps in the development of tools to accurately assess STBs in young children in need of life saving intervention. Further, the proposed supplement falls within, and enriches, the scope of the parent grant. The parent grant investigates early origins of anhedonia and as STBs often accompany or follow anhedonia, this supplement provides an important complementary outcome measure. Additionally, the parent grant probes the role of unpredictable early life experiences in psychopathology and Aim 3 of the supplement enables assessment of the role of unpredictability in STBs. The present study has the potential to transform the study of STBs in children, by enhancing parent consent to assessment of STBs and increasing confidence in the validity of STB assessment in children.