Genetic programs orchestrated by AP-1 transcription factors in colorectal cancer progression

结直肠癌(colorectal?cancer,CRC)是全球第三大癌症。大约一半的确诊患者死于该病在体内的传播。该项目将研究一种特异性DNA结合蛋白在协调CRCs传播所需基因表达程序中所起作用。该研究将为CRC进展的潜在机制提供新的见解，并为该疾病的侵袭性形式确定新的治疗靶点。

Colorectal cancer (CRC) is the third most common cancer worldwide. About half of all patients diagnosed with the disease die as a result of its spread in the body. This project will investigate the role that a specific DNA-binding protein plays in orchestrating gene expression programs required for CRCs to spread. The research will provide new insights into underlying mechanisms of CRC progression as well as identify new therapeutic targets for aggressive forms of the disease.