Mechanistic basis of AP-1-regulated gene expression during colorectal cancer progression

结直肠癌进展过程中 AP-1 调控基因表达的机制基础

• 批准号: nhmrc : 1044168
• 负责人: Dr Amardeep Dhillon
• 金额: $ 39.86万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanistic-basis-ap-cancer-progression/111634
• 关键词: Mechanistic; basis; AP; regulated; gene

The spread of colorectal cancers in the body poses a major clinical problem for which current treatment options are inadequate. This project aims to unravel how a specific DNA-binding protein regulates the expression of genes involved in the spread of these cancers. The research is expected to provide a better mechanistic understanding of how disease progression occurs and to identify novel strategies to treat aggressive tumours.

结直肠癌在体内的扩散构成了一个主要的临床问题，目前的治疗方案是不够的。该项目旨在揭示特定的DNA结合蛋白如何调节参与这些癌症扩散的基因的表达。该研究有望提供对疾病进展如何发生的更好的机制理解，并确定治疗侵袭性肿瘤的新策略。